guaB1
mL2066
PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 2453707 – 2455143
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL2066_guaB1_dna
TTCTGGACGGGCACCAGCCCAGGTTCGACCTAACCTATAAAGACGTTTTCATCGTGCCACACCGGTCGGATGTTGCGTCGCGATTTGACGTCGATTTGTCAACCTATGACGGCTCCGGCACCACTATTCCCGTAGTGGTCGCCAACATGACCACGGTGGCCGGGCAACGGATGGCAGAGACGGTAGCTCGCCGGGGCGGCTTAGTAATTTTACCGCAGGATCTGCCGATTGCAACAGTGCAGCAGGCAGTGGAGTTCGTCAAGAGCCGTGACCTGGTTATCGATACCCCGGTGTTACTGACACCTAACGATTCGGTGTCCGACGCGACCACACTGATCCACAAGCGCGCGCACGGTGTTGCGGTGGTGGCCTTCGAAGGCCGCCCAATTGGTCTGGTGCGCGAATCGTCTTGCCTAGGTGTGGACCGCTTCACTCGGGTGCGGGATGTCGCGACTACCGACTTTGTAACCGCCCCGGTGGGCACCGATCCACGCAAGATCTTCGACCTGCTCGAACATGCCCCGATCGACGTCGCGGTGCTGACTAACGCCGACGGCACGCTGGCCGGAGTACTGACCCGCACCGGGGCGATCCGCGCCGGCATCTACACCCCAGCCACCGATGCCCGCGGACGGCTCCGCATCGGTGCTGCTGTCGGCATAAACGGCGATGTAGCCGGCAAGGCCCAGTCCCTCGCCGAGGCAGGTGTCGATGTGCTGGTCGTCGACACCGCACACGGATACCAAGTCAAGACACTCGAGGCGATCAAATGCGTCGCATCGCTGAACTTGGGTGTGCCGTTGGTCGCGGGCAACGTGGTGTCGGCTGAAGGTACTCGCGAGCTACTCAACGCCGGGGCGACCATCGTCAAGGTCGGCGTCGGCCCAGGAGCAATGTGCACAACTCGGATGATGACCGGTGTTGGCCGACCGCAATTCTCAGCTGTACTCGAATGTGCCTCTGCTGCAAGGAAACTCAATAGGCACGTGTGGGCTGATGGAGGAGTCCGCCATCCGCGTGACGTGGCGCTGGCGTTGGCCGCAGGAGCATCGAACGTGATGATCGGGTCGTGGTTCGCCGGGACTTATGAGTCACCCGGGGACCTCATGCGGGACCGCCACGACCAACCGTACAAGGAAAGCTACGGCATGGCGTCCAAGCGAGCGGTGGTTGCCCGCACCGTTGCCGACAGCTCATTCGATCGCGCTCGCAAGGCGTTATTCGATGAAGGCATCTCGACCTCACGGATGGGGCTGGATCCCGACCACGGTGGTGTCGAGGACCTGATCGATCACATCACCTCCGGCGTGCGCAGCACCTGCACCTATGTCGGCGCGTCGACCCTGGCGGAGCTGCATGAGAAGGCTGTCGTCGGGGTGCAGTCAGCGGCGGGTTTCGCCGAGGGCCATCCACTGCCCTCGGGGTGGTGACACCTGA

Protein Sequence 

>ML2066_GuaB1_protein
FWTGTSPGST_PIKTFSSCHTGRMLRRDLTSICQPMTAPAPLFP_WSPT_PRWPGNGWQRR_LAGAA__FYRRICRLQQCSRQWSSSRAVTWLSIPRCY_HLTIRCPTRPH_STSARTVLRWWPSKAAQLVWCANRLA_VWTASLGCGMSRLPTL_PPRWAPIHARSSTCSNMPRSTSRC_LTPTARWPEY_PAPGRSAPASTPQPPMPADGSASVLLSA_TAM_PARPSPSPRQVSMCWSSTPHTDTKSRHSRRSNASHR_TWVCRWSRATWCRLKVLASYSTPGRPSSRSASAQEQCAQLG__PVLADRNSQLYSNVPLLQGNSIGTCGLMEESAIRVTWRWRWPQEHRT__SGRGSPGLMSHPGTSCGTATTNRTRKATAWRPSERWLPAPLPTAHSIALARRYSMKASRPHGWGWIPTTVVSRT_SITSPPACAAPAPMSARRPWRSCMRRLSSGCSQRRVSPRAIHCPRGGDT

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding GuaB1 with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

2 show intermediate predicted evidence for PPIs

35 show weak predicted evidence for PPIs

View all pooled AlphaFold results for GuaB1

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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