gcvB
mL2072c
Probable glycine dehydrogenase GcvB (Glycine decarboxylase) (Glycine cleavage system P-protein)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 2463426 – 2466284
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL2072c_gcvB_dna
TTTCTGAGTGTCGGTACCGAACTCATCGAACAAGCAGACCTGCTTTACAGCCCGGCATATTGGCCCTAACAGCGAGGACGTTGCGACCATGCTTGCAGTCATCGGCGTCGAATCGCTAGACGATCTGGCAGCTAAGGCAGTTCCTAGCGACATTCTCGATAATGTCACCGACACCGGCGTTGCACCGGGCCTGGACCGGTTGCCGCCGCCGGCTACCGAGTCCGAGACGCTAGCCGAGCTAGGTGCGCTTGCTCGTGCTAATACCGTTGCCGTATCGATGATCGGGCAGGGCTACTACGACACCCTCACGCCAGCGGTGCTGTCGCGCAACATCTTGGAGAACCCGGCCTGGTATACTCCCTATACGCCGTACCAGCCCGAAATCAGTCAGGGTCGGCTGGAAGCGTTGCTGAATTTCCAGACTCTGGTCAGCGATCTTACTGGCTTGGAGATCGCAAACGCATCGATGCTCGACGAGGGCACAGCAGCAGCCGAGGCCATGACATTGATGTACCGTGCTGCCCGCAGTACGGCGAGCCGGGTGGTCGTTGACGTCGACGTGTTTGCCCAGACTGTCGCAGTGTTCGCCACTCGGGCCAAACCGTTAGGCATCGACATCGTTGTGGCCGACCTACGCGAAGGACTACCGGACGGTGAGTTCTTTGGCGTCATCACCCAACTTCCCGGAGCCAGCGGCCGGATTACCGACTGGACCGCTTTAATCGCCCAGGCCCACAGCCGCGGCGCATTGGTCGCTGTCGGTGCCGATCTGTTAGCGCTGACGTTGATTACGCCACCGGGCGAGATCGGCGCCGACGTCGCATTCGGTACTACTCAGAGGTTCGGCGTGCCAATGGGATTTGGTGGCCCGCATGCTGGATACCTCGCCCTGCACACTAAGCATGCCCGTCAGCTGCCGGGTCGGTTGGTAGGTGTTTCTGTCGACAGCGACGGCACACCGGCCTACCGGTTGGCGCTGCAGACCCGCGAGCAACATATCCGCCGAGACAAGGCGACAAGCAACATCTGCACCGCACAGGTGCTGTTGGCGGTGATGGCTGCGATGTACGCCAGTTACCATGGTGCCGAGGGATTGACCGGTATCGCGCGGCGGGTGCATGCACAGGCACGCGCCCTGGCGGCCGGTCTGTCCGCAGCCGGTGTTGAGGTGGTACACCAGGCGTTCTTCGACACCGTGCTGGCCCGGGTACCCGGCCGGACGGTGCAAATTCAGGGCGCTGCGAAGGAGCGCGGTATCAATGTCTGGCTCGTGGACGGCGACCATGTTTCGGTGGCCTGTGACGAGGCCACCACCGATGAGCACATCACGGCCGTGTTGGCGGCGTTCGCAGCGACGCCGGCGCGGGCGAGCTTCGCCGGTCCGGATATCGCGACCCGAACCTCGGCGTTCCTGACGCATCCGACATTTACCAAGTACCGCACCGAAACTTCAATGATGCGGTACTTGCGTGCCTTGGCGGATAAGGATATCGCTCTGGACCGCAGCATGATTCCGCTCGGTTCGTGCACGATGAAGCTCAACGCCGCCGCCGAGATGGAGTCGATTACCTGGCAGGAATTCACGCGCCAGCATCCATTCGCACCAGTATCAGACACCCCCGGGCTGCGTCGTCTCATTAGCGACTTGGAGAGCTGGCTGGTGCAGATTACCGGCTACGATGCGGTTTCCTTGCAGCCCAACGCGGGCTCTCAGGGGGAGTACGCTGGTCTGTTGGCGATTCACGACTACCACGTCAGCCGAGGGGAACCGCACCGCAACGTCTGTTTGATTCCGTCAAGCGCGCATGGCACCAACGCCGCATCGGCGGCGTTGGTCGGTATGCGCGTGGTCGTGGTGGGTTGCCACGATAACGGTGACGTTGATCTTGACGATCTACGTATCAAGCTCAGCGAGCATGCCAACCGGCTGTCCGTGTTAATGATCACCTATCCGTCCACACACGGCGTCTATGAGCATGACATTGCCGAGATCTGCGCGGCGGTGCATGACGCCGGTGGTCAAGTTTATGTCGATGGGGCCAACCTCAACGCGCTGGTCGGCCTGGCCCGGCCGGGCAAGTTTGGTGGCGACGTCAGCCACCTGAACCTGCACAAAACGTTTTGCATCCCGCACGGTGGCGGAGGACCAGGAGTCGGGCCGGTGGCGGTTCGTTCGCATTTGGTCTCGTTTCTGCCGGGTCACCCCTTTGCTCCCGAACTGCCGCAAGGTCAGCCGGTGTCGTCGGCGCCGTATGGGTCCGCCTCACTCCTGCCGATCACGTGGGCCTATATCAGGATGATGGGCGCCGACGGTCTGCGAACGGCATCGCTGACCGCAATCGCCTCGGCCAACTACATAGCCCGTCGGCTCGACAAATACTTCCCGGTGCTGTACACCGGCGAGAACGGAATGGTCGCCCACGAGTGCATCCTGGACTTGCGACCGATCACCAAGTCGGTTGGTGTGACTGTCGACGATGTTGCTAAACGCTTGGCGGATTATGGTTTTCACGCGCCCACGATGAGCTTCCCGGTGCCCGGAACGCTGATGGTGGAACCCACCGAGAGTGAGAGCCTGGCCGAAATTGATGCATTTTGCGAGGCCATGATCGCCATCCGTGGCGAGATCGCCCGCGTCGGTGCAGGGGAGTGGTCTGTTGAGGACAACCCACTACGCGGCGCACCGCACACCGCTGAGTGCCTGCTGGCCTCCGACTGGGATCATCCGTATACCCGAGAAGAGGCCGCTTATCCGCTTGGCAAAGCGTTCCGGCCGAAGGTGTGGCCGCCGGTGCGTCGTATCGACGGTGTCTACGGCGACCGCAATTTGGTGTGCTCGTGCCTGCCGGTGGAGGCGTT

Protein Sequence 

>ML2072c_GcvB_protein
FLSVGTELIEQADLLYSPAYWP_QRGRCDHACSHRRRIARRSGS_GSS_RHSR_CHRHRRCTGPGPVAAAGYRVRDASRARCACSC_YRCRIDDRAGLLRHPHASGAVAQHLGEPGLVYSLYAVPARNQSGSAGSVAEFPDSGQRSYWLGDRKRIDARRGHSSSRGHDIDVPCCPQYGEPGGR_RRRVCPDCRSVRHSGQTVRHRHRCGRPTRRTTGR_VLWRHHPTSRSQRPDYRLDRFNRPGPQPRRIGRCRCRSVSADVDYATGRDRRRRRIRYYSEVRRANGIWWPACWIPRPAH_ACPSAAGSVGRCFCRQRRHTGLPVGAADPRATYPPRQGDKQHLHRTGAVGGDGCDVRQLPWCRGIDRYRAAGACTGTRPGGRSVRSRC_GGTPGVLRHRAGPGTRPDGANSGRCEGARYQCLARGRRPCFGGL_RGHHR_AHHGRVGGVRSDAGAGELRRSGYRDPNLGVPDASDIYQVPHRNFNDAVLACLGG_GYRSGPQHDSARFVHDEAQRRRRDGVDYLAGIHAPASIRTSIRHPRAASSH_RLGELAGADYRLRCGFLAAQRGLSGGVRWSVGDSRLPRQPRGTAPQRLFDSVKRAWHQRRIGGVGRYARGRGGLPR_R_R_S_RSTYQAQRACQPAVRVNDHLSVHTRRL_A_HCRDLRGGA_RRWSSLCRWGQPQRAGRPGPAGQVWWRRQPPEPAQNVLHPARWRRTRSRAGGGSFAFGLVSAGSPLCSRTAARSAGVVGAVWVRLTPADHVGLYQDDGRRRSANGIADRNRLGQLHSPSARQILPGAVHRRERNGRPRVHPGLATDHQVGWCDCRRCC_TLGGLWFSRAHDELPGARNADGGTHRE_EPGRN_CILRGHDRHPWRDRPRRCRGVVC_GQPTTRRTAHR_VPAGLRLGSSVYPRRGRLSAWQSVPAEGVAAGASYRRCLRRPQFGVLVPAGGGV

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding GcvB with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

1 shows intermediate predicted evidence for PPIs

31 show weak predicted evidence for PPIs

View all pooled AlphaFold results for GcvB

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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