prrB
mL2124
TWO COMPONENT SENSOR HISTIDINE KINASE PRRB
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 2524876 – 2526216
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL2124_prrB_dna
TCCTGTCGCGAATCTTCGCCCGTACGCCGTCGTTGCGAACCCGGGTGGTGGTCGCTACGGCCATCGGTGCAGCGATTCCGGTTCTCATCGTCGGCACAGTCGTCTGGGTCGGGATCACCAACGACCGCAAAGAGCGGCTGGACCGCAAACTGGATGAGGCAGCCGGTTTCGCGATCCCGTTCGTGCCGCGCGGCCTTGACGAAATTCCGCGCTCGCCTAACGACCAGGACGCCATCATCACCGTGCGCCGCGGCAACTTGGTCAAGTCGAATTTCGACATCACGCTGCCCAAACTGACAAACGACTACGCTGATACCTACCTCCGCGGGGTACGCTACCGAGTACGGACGGTGGAGATCCCAGCACCGGAGCCGACATCAATTGCTGTCGGCGCGACGTACGACGCCACCGTCGCCGAGACCAACAACTTGCACCGCCGAGTGCTACTGATCTGTGGATTCGCCATCGCTGCGGCGGCCGTTTTCGCCTGGCTGCTGGCCGCATTCGCAGTGCGCCCGTTCAAACAGCTTGCTCAGCAGACCCGATCAGTCGATGCCGGCGGTGAGGCACCACGGGTGGAGGTGCACGGCGCCACCGAAGCCGTTGAGATCGCCGAGGCGATGAGAGGAATGCTGCAGCGTATCTGGAATGAACAGAACCGGACCAAGGAGGCGCTGGCCTCGGCCCGCGATTTCGCTGCAGTGTCCTCCCATGAACTACGCACACCATTGACTGCGATGCGCACTAATCTCGAAGTGCTTGCCACCCTGGACTTGGCCGACGACCAACGCAAAGAAGTCCTGGGCGACGTGATCCGCACCCAGTCGCGGATAGAGGCCACCCTCAGCGCGCTGGAGCGGTTGGCCCAGGGAGAACTGTCGACGTCGGACGATCACGTGCCAGTCGACATCACTGAGTTGCTCGACCGTGCCGCCCACGACGCGACTCGGAGCTACCCTGAGCTCAAAGTCTCGCTGGTGCCGTCGCCGACCTGCATCATTGTGGGGTTGCCAGCCGGGTTACGACTTGCCGTCGACAACGCGGTCGCCAATGCCGTGAAACATGGCGGCGCCACCCGAGTCCAGCTGTCCGCGGTCAGTTCGCGGGCCGGGGTAGAAATTGCCGTCGACGACAACGGCAGTGGAGTGCCCGAAGATGAGCGCCAAGTGGTGTTTGAACGGTTTTCTCGAGGATCGACGGCCTCCCACTCGGGATCGGGTCTGGGGCTGGCGCTGGTGGCCCAGCAGGCCCAGCTACACGGCGGGACGGCTTCATTGGAAACTAGCCCGCTGGGCGGCGCGCGGCTGCTGCTGCGTATATCCGCGCCCAGCTAACCGAAAG

Protein Sequence 

>ML2124_PrrB_protein
SCRESSPVRRRCEPGWWSLRPSVQRFRFSSSAQSSGSGSPTTAKSGWTANWMRQPVSRSRSCRAALTKFRARLTTRTPSSPCAAATWSSRISTSRCPN_QTTTLIPTSAGYATEYGRWRSQHRSRHQLLSARRTTPPSPRPTTCTAECY_SVDSPSLRRPFSPGCWPHSQCARSNSLLSRPDQSMPAVRHHGWRCTAPPKPLRSPRR_EECCSVSGMNRTGPRRRWPRPAISLQCPPMNYAHH_LRCALISKCLPPWTWPTTNAKKSWAT_SAPSRG_RPPSARWSGWPRENCRRRTITCQSTSLSCSTVPPTTRLGATLSSKSRWCRRRPASLWGCQPGYDLPSTTRSPMP_NMAAPPESSCPRSVRGPG_KLPSTTTAVECPKMSAKWCLNGFLEDRRPPTRDRVWGWRWWPSRPSYTAGRLHWKLARWAARGCCCVYPRPANRK

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding PrrB with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

1 shows intermediate predicted evidence for PPIs

42 show weak predicted evidence for PPIs

View all pooled AlphaFold results for PrrB

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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