purL
mL2211c
PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE II PURL (FGAM SYNTHASE II)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 2626960 – 2629224
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL2211c_purL_dna
CACACGCGTGATTGACACCGTTGAATATGCTGCTACCACCCCCGACCAGCCGCAACCGTTTGCTGAGCTGGGCCTCAGAGAGGACGAGTACCAGCGAGTTCGCGAAATTCTAGGTCGGCGACCTACGGACACCGAGCTGGCGATGTATTCGGTGATGTGGAGTGAGCACTGTTCGTACAAGTCTTCCAAAGTTCACCTGCGTTACTTCGGTGAAACCACCACCGAGGAGATGCGTACCGGAATGCTGGCCGGTATCGGTGAAAATGCTGGTGTTGTCGACATCGGTGACGGCTGGGCCGTCACTTTCAAGGTAGAATCGCACAACCACCCTTCTTATGTCGAGCCGTACCAGGGGGCCGCAACCGGCGTCGGCGGCATCGTACGTGACATCATGGCGATGGGCGCGCGACCTGTCGCTGTGATGGACCAGCTTCGGTTCGGTGCTGCCGATGCGCTCGATACCCGCCGCGTGCTGGATGGCGTGGTCCGCGGTATTGGCGGCTACGGCAACTCGCTGGGCTTGCCCAACATCGGCGGCGAGACTGTCTTCGACTCGTGCTACGACGGCAATCCTCTGGTGAATGCGTTGTGTGTCGGGGTGTTACGCCAGGAGGATCTTCATTTGGCGTTTGCCTCGGGTGCGGGTAACAAGATCATTCTGTTCGGCGCGTGTACCGGGCTGGACGGTATCGGCGGGGTCTCGGTGTTGGCGTCGGACACCTTCGATGCTGAAGGAGCGCGGAAGAAACTCCCGTCGGTTCAGGTGGGTGACCCCTTTATGGAAAAGGTACTCATCGAGTGCTGTCTGGAATTGTATGCTGGCGGGCTGGTGATCGGCATCCAAGACTTAGGAGGTGCAGGATTATCTTGTGCCACTTCGGAGTTGGCATCAGCTGGGGACGTCGGAATGGCGATTCAACTCGACACCGTCCCGCGCCGCGCGAAGGATATGACGCCCGCCGAGGTGTTCTGCAGCGAATCGCAGGAGCGCATGTGCGCGGTGGTTGCACCGGAGAACGTGGACGCCTTCTTGGCGGTCTGCCGCAAATGGGAGGTGCTGGCCACGGTGATTGGTGAGGTCACCGACGGCGACCGACTACGGATCACCTGGCACGGCGAGACAGTCGTCGACGTGCCACCGCGCACCGTGGCCCATGAGGGACCGGTGTATCAGCGACCCGTCTCCCGCCCCGAATCACAGGAAGCCTTGAACGCGGATTCATCGAAAGGATTGCCGCGACCGGTTAGCGGAGACGAGCTGCGTGCGACTTTGCTTGCACTGCTGGGTAGTCCGCACTTGTGCAGCCGGGCTTTCATCACCGAGCAGTATGATCGGTATGTGCGCGGCAACACCGTCTTGGCCGAGCATGCCGACGCTGGCGTGCTGCGTATCGACGAGTCCACCGGCCGCGGTATTGCGTTGTCGACCGACGCGTCTGGACGCTATACCCGGCTAGATCCCTATGCCGGTGCCCAACTGGCGCTGGCCGAGGCGTACCGCAACGTGGCTGTCACCGGTGCCACCCCGGTCGCGGTGACCAACTGCCTCAACTTCGGTTCACCCGAAGATCCAGGAGTGATGTGGCAGTTCGCGCAGGCTGTGCGGGGGCTGGCTGATGGTTGTGCGGCCCTGAAGATTCCTGTAACCGGCGGCAACGTCAGCTTTTACAATCAAACGGGGGCGGTGGCGATCTTGCCCACGCCGGTGGTTGGGGTGCTCGGCGTCCTGGATAACGTGGCTAGACGTATCCACACGTCCTTAGGCACTGAACCTGGAGAGATTCTGATGTTGCTGGGTGACACCTATGACGAGTTCGACGGGTCCGTCTGGGCGCAAGTGATGGCTGGCCACCTGGGTGGGCTGCCGCCCATGGTGGACTTGGCGCGTGAGAAGCTGCTGGCCGAGGTGCTGAGTTCGGCGTCGCGCGACGAGCTGGTATCGGCAGCTCATGACCTGTCCGAAGGCGGCCTCGCCCAGGCTATCGTGGAATCGGCGTTGGCGGGTGAAACTGGTTGCCGTATAGCGCTTCCCGAAGATGCTGATCCGTTCGTGATGCTCTTTTCCGAATCAGCAGGTCGGGTGCTGGTAGCTGTGCCACGCCCCGAAGAGAGCCGGTTTCGGTCGATGTGCGAGGCGCGAGGTTTGCCAGCTATGCGTATCGGTGTGGTCGATCAGGGTTCGGACTCGATAGAGGTTCGGGGTCAATTCACCGTGTCCCTGGCAGAACTGCGTATGACGTTCGAGGCGGTGCTGCCGCGATTTTT

Protein Sequence 

>ML2211c_PurL_protein
HTRD_HR_ICCYHPRPAATVC_AGPQRGRVPASSRNSRSATYGHRAGDVFGDVE_ALFVQVFQSSPALLR_NHHRGDAYRNAGRYR_KCWCCRHR_RLGRHFQGRIAQPPFLCRAVPGGRNRRRRHRT_HHGDGRATCRCDGPASVRCCRCARYPPRAGWRGPRYWRLRQLAGLAQHRRRDCLRLVLRRQSSGECVVCRGVTPGGSSFGVCLGCG_QDHSVRRVYRAGRYRRGLGVGVGHLRC_RSAEETPVGSGG_PLYGKGTHRVLSGIVCWRAGDRHPRLRRCRIILCHFGVGISWGRRNGDSTRHRPAPREGYDARRGVLQRIAGAHVRGGCTGERGRLLGGLPQMGGAGHGDW_GHRRRPTTDHLARRDSRRRATAHRGP_GTGVSATRLPPRITGSLERGFIERIAATG_RRRAACDFACTAG_SALVQPGFHHRAV_SVCARQHRLGRACRRWRAAYRRVHRPRYCVVDRRVWTLYPARSLCRCPTGAGRGVPQRGCHRCHPGRGDQLPQLRFTRRSRSDVAVRAGCAGAG_WLCGPEDSCNRRQRQLLQSNGGGGDLAHAGGWGARRPG_RG_TYPHVLRH_TWRDSDVAG_HL_RVRRVRLGASDGWPPGWAAAHGGLGA_EAAGRGAEFGVARRAGIGSS_PVRRRPRPGYRGIGVGG_NWLPYSASRRC_SVRDALFRISRSGAGSCATPRREPVSVDVRGARFASYAYRCGRSGFGLDRGSGSIHRVPGRTAYDVRGGAAAIF

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding PurL with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

3 proteins show strong predicted evidence for PPIs

10 show intermediate predicted evidence for PPIs

60 show weak predicted evidence for PPIs

View all pooled AlphaFold results for PurL

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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