otsA
mL2254
PROBABLE ALPHA%2C ALPHA-TREHALOSE-PHOSPHATE SYNTHASE [UDP-FORMING] OTSA (TREHALOSE-6-PHOSPHATE SYNTHASE) (UDP-GLUCOSE-GLUCOSEPHOSPHATE GLUCOSYLTRANSFERASE) (TREHALOSEPHOSPHATE-UDP GLUCOSYLTRANSFERASE) (TREHALOSE-6-PHOSPHATE SYNTHETASE) (TREHALOSE-PHOSPHATE SYNTHASE) (TREHALOSE-PHOSPHATE SYNTHETASE) (TRANSGLUCOSYLASE) (TREHALOSEPHOSPHATE-UDP GLUCOSYL TRANSFERASE)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 2677270 – 2678766
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL2254_otsA_dna
CGCGGGGTAACCATGGCTCGAAGACCTCAAGTGACAAGCACCTCGGGGATTCCGACTTTGTAGTGGTCGCCAATCGCCTGCCAGTTGATCAGGTGCGACTTCCCGATGGCACTGCGATCTGGAAGCGCAGTCCAGGCGGGTTGGTCACAGCGCTAGAGCCGCTGCTGCGTCAGCGGCGCGGGGCCTGGGTCGGCTGGCCGGGCGTAATAAACGACAACGTGGACCTCGACTTGACCATCAAGTCGATCGTGCAGGATGGCCTTACTCTTTATCCGGTACGGCTGAACACACATGATGTCGCCGAGTACTACGAGGGGTTCTCGAACGCCACGCTGTGGCCGCTATACCACGACGTCATCGTAAAGCCCATTTACCACTGCGAATGGTGGGAACGCTACGTCGATGTCAACCGGCGCTTCGCCGAAACAACGTCACGCACAGCCGCCTACGGTGGGACCGTATGGGTGCAGGACTACCAACTGCAATTGGTACCGAAGATGCTGCGCATAATGCGGCCCGACTTGACCATCGGTTTCTTCTTGCACATCCCGTTCCCGCCGGTGGAGCTGTTCATGCAGATACCATGGCGCACCGAGATCATCGAGGGTCTGCTCGGGGCCGACCTAGTGGGATTCCATCTGACCAGCGGTGCGCAGAATTTCCTGTTCCTGTCCCGACATCTGCTCGGCGCTAACACGTCGCGCGGATTGGTTGGTGTGCGATCACGGTTCGGTGAAGTGCAATTGAAGTCCCACACAGTCCAAGTGGGCGCGTTTCCCATCTCGATCGACTCCAAAGAAATCGACCAAGCCACCCGCGACCGCAACGTCCGGCGCCGCGCCCGCGAAATCCGGGCTGAGCTAGGTAACCCCCGCAAAATCCTGCTCGGCGTTGACCGACTCGACTACACCAAGGGCATCGATGTTCGATTGAGGGCCTTCGCTGAACTGCTCGCCGAGGGTCGGGCGAAGCGCGACGACACCGTTCTAGTCCAGCTAGCGACACCGAGCCGCGAACGAGTAGAAAGCTATAAGATTTTACGCAACGACATCGAACGCCAAGTTGGCCATATCAACGGCGAATACGGCGAGGTCGGTCATCCCGTGGTGCACTACTTGCACCGCCCAATTCCCCGCGACGAGCTCATCGCGTTCTACGTGGCAAGTGATGTCATGTTGGTCACCCCGCTGCGGGACGGGATGAACCTAGTGGCCAAGGAATACGTCGCGTGCCGCAACGATCTCGGCGGTGCGCTCGTCCTCAGCGAATTCACCGGAGCAGCCGCGGAACTCCGGCAGGCCTATCTAGTCAACCCACACGACCTAGAAGGGGTTAAGGACACGATCGAAGCGGCGCTCAACCAGCTGGCCGAAGAAGCACGGCGCCGGATGCGGTCGCTGCGACGCCAAGTGCTCGCCCATGACGTCGATCGCTGGGCGCGATCATTTCTCGACGCGCTCGCCGAAGCGCCGGCGCGCGACGCGACATAACTTGCAT

Protein Sequence 

>ML2254_OtsA_protein
RGVTMARRPQVTSTSGIPTL_WSPIACQLIRCDFPMALRSGSAVQAGWSQR_SRCCVSGAGPGSAGRA__TTTWTST_PSSRSCRMALLFIRYG_THMMSPSTTRGSRTPRCGRYTTTSS_SPFTTANGGNATSMSTGASPKQRHAQPPTVGPYGCRTTNCNWYRRCCA_CGPT_PSVSSCTSRSRRWSCSCRYHGAPRSSRVCSGPT_WDSI_PAVRRISCSCPDICSALTRRADWLVCDHGSVKCN_SPTQSKWARFPSRSTPKKSTKPPATATSGAAPAKSGLS_VTPAKSCSALTDSTTPRASMFD_GPSLNCSPRVGRSATTPF_SS_RHRAANE_KAIRFYATTSNAKLAISTANTARSVIPWCTTCTAQFPATSSSRSTWQVMSCWSPRCGTG_T_WPRNTSRAATISAVRSSSANSPEQPRNSGRPI_STHTT_KGLRTRSKRRSTSWPKKHGAGCGRCDAKCSPMTSIAGRDHFSTRSPKRRRATRHNLH

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding OtsA with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

0 show intermediate predicted evidence for PPIs

11 show weak predicted evidence for PPIs

View all pooled AlphaFold results for OtsA

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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