menD
mL2270
PROBABLE BIFUNCTIONAL MENAQUINONE BIOSYNTHESIS PROTEIN MEND : 2-SUCCINYL-6-HYDROXY-2%2C4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE (SHCHC SYNTHASE) + 2-OXOGLUTARATE DECARBOXYLASE (ALPHA- KETOGLUTARATE DECARBOXYLASE) (KDC)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 2693812 – 2695482
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL2270_menD_dna
CCTCGACGACACAGGCTCGCGTCGTCGTTGACGAGCTGATCCGCGGCGGCGTCCGCGATGTAGTGCTGTGCCCCGGGTCGCGAAACGCCCCGTTGGCATTCGCCCTGCAAGACGCCGACCACGCCGGCCGGATACGGCTGCACGTACGCATTGACGAGCGCACCGCCGGGTATCTGGCTATCGGGCTGGCGGTCGCCGCGGGCGCGCCGGTGTGTGTGGCGATGACCTCGGGCACTGCCGTCGCCAACCTTGGCCCAGCGGTGGTCGAAGCCAACTATGCCCGGGTGCCACTGATCGTGTTATCGGCCAACCGGCCTTATGAATTGCTCGGCACAGGGGCCAACCAGACCATGGAGCAGCTGGGCTACTTCGGCACCCAAGTTCGTGCCGCCATCAGCCTAGGCCTAGCAGAGGACGCGCCGGAGCGGCTCGATTCACTCAACGCAACCTGGCGATCGGCCACCTGCCGAGTATTGGTGGCTGCCACCGGTTCTCGTACCGCCAACGCCGGCCCCGTGCAGTTCGACATCCCACTGCGCGAGCCTTTAATACCCGACCCGGAACCCCACGGCGCCATCACACCGCAGGGCCGGCCCGGCGGAAAGCCGTGGACCTACATACCGCAGGTGACGTTCGACCAGCCGCTGGAAATCGACTTGTCAGCCGACACCGTCGTCATCGCCGGGCACGGTGCAGGCGTGCACCCGAACCTGACCGAATTGCCGATCGTTGCTGAGCCGACCGCGCCATTTGGACCGTACCGGCCCTACCCGTTGCACCCCCTAGCGCTGCCTCTGCTGCACCCGAAGCAGGTGATCATGCTCGGTCGCCCGACACTGCACCGCCCGGTGTCGGCGCTACTGGCCGACCCACAAGTGCCGGTGTACGCGCTTACCACTGGGCCGTGTTGGCCGGACGTCTCGGGCAATTCTCAGGCCGCTGGTACTCGGGCGGTAACCACCGGGACACCGCATCCGGCCTGGCTGCAGCGCTGTGCGGAGATGAACCAGCACGCGATCTCGACGGTGCGCAGCCAGCTCGCGGCTCATCCGTTAATCACGGGTTTGCATGTCGCTGCAGCTGTGGCAGATGCACTACGGCCCGGTGACCAACTGGTGCTTGGGGCGTCCAACCCGGTGCGCGACATGGCGTTGGTTGGTTTGTCCACTGACGGTATTCAGGTGCGGTCCAACCGCGGCGTCGCTGGCATCGACGGCACCGTATCCACCGCGATCGGGGCGGCGCTAGCATATGAACGATCCCCCGGCTACGCTGGTAGCACAGACCGCCCGGCTCGTACCGTAGCATTAATCGGAGACCTCGCATTCGTCCATGACAGCTCGGGGCTGTTGATCGGCCCCACCGAACCCACACCGCAGCAGCTGAAAATCGTAGTGTCTAACGACAACGGTGGGGGTATCTTCGAACTGCTGGAGCAAGGCGACCCGAGGTTGTCTGCCGTATCGTCGCGCATCTTCGGTACTCCGCACGACGTCGACGTAGGAGCGTTGTGTCGCGCGTACCACGTGGAAGGTCGACAGATCGAGGTCGACAAGCTGCGGGAAGCCCTCGACGAACCCGGTGTTGGCATGCGCGTGCTGGAAGTCAAGGCCGACCGATCTTCGCTGCGCCAGTTGCATGCAGCAATCACGGCAACATTGTGAGGTTGCT

Protein Sequence 

>ML2270_MenD_protein
PRRHRLASSLTS_SAAASAM_CCAPGRETPRWHSPCKTPTTPAGYGCTYALTSAPPGIWLSGWRSPRARRCVWR_PRALPSPTLAQRWSKPTMPGCH_SCYRPTGLMNCSAQGPTRPWSSWATSAPKFVPPSA_A_QRTRRSGSIHSTQPGDRPPAEYWWLPPVLVPPTPAPCSSTSHCASL_YPTRNPTAPSHRRAGPAESRGPTYRR_RSTSRWKSTCQPTPSSSPGTVQACTRT_PNCRSLLSRPRHLDRTGPTRCTP_RCLCCTRSR_SCSVARHCTARCRRYWPTHKCRCTRLPLGRVGRTSRAILRPLVLGR_PPGHRIRPGCSAVRR_TSTRSRRCAASSRLIR_SRVCMSLQLWQMHYGPVTNWCLGRPTRCATWRWLVCPLTVFRCGPTAASLASTAPYPPRSGRR_HMNDPPATLVAQTARLVP_H_SETSHSSMTARGC_SAPPNPHRSS_KS_CLTTTVGVSSNCWSKATRGCLPYRRASSVLRTTST_ERCVARTTWKVDRSRSTSCGKPSTNPVLACACWKSRPTDLRCASCMQQSRQHCEVA

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding MenD with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

0 show intermediate predicted evidence for PPIs

6 show weak predicted evidence for PPIs

View all pooled AlphaFold results for MenD

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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