ponA2
mL2308
PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE (PEPTIDOGLYCAN TGASE) + PENICILLIN-SENSITIVE TRANSPEPTIDASE (DD-TRANSPEPTIDASE)]
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 2732194 – 2734605
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL2308_ponA2_dna
AGCGCCTCCCAGCCGTCCTCGCAGTTCTCAAGCTTGCGGGGTATTGCCTATTGGCCGGCGTTGTCACCACCGCAATGATGTTCCCGTTGGCCGGCGGACTGGGGGTGATATCCAACCGTGCTTCGGAAGTGGTAGCCAACGGATCGGCCCAACTTCTCGAGGGCGAGGTGCCCGCGGTATCGACAATGGTCGACGCGAAGGGAAACACGATCGCGTGGCTGTACTCGCAACGCCGATTCGAGGTACCCACCGACAAGATCGCCAACACCATGAAGCTGGCCATCGTTTCCATCGAGGATAAACGCTTTACCGACCACAACGGTGTGGACTGGCCGGGCACCCTGACCGGACTGGCCGGCTACGCATCCGGCGACGTGGACACTCGCGGCGGTTCGACGATCGAGCAGCAGTACGTGAAAAACTATCAGTTACTGGTAACCGCTCAAACCGACGCCGAAAAACGTGCGGCCGTCGAAACCACCCCGGCACGCAAGCTGCGCGAGATCCGGATAGCGCTCACGCTGGACAAGACGTTCACCAAACCCGAGATCCTGACCCGCTACTTGAACCTGGTGTCGTTCGGCAACAACTCTTTCGGCGTGCAAGATGCAGCGCAGACCTACTTCGGCGTCAACGCGTCCGACCTAAATTGGCAACAAGCAGCACTACTCGCCGGCATGGTGCAATCGACCAGCACGCTCAACCCGTACACCAACCCTGAAGGCGCGTTGGCCCGGCGAAACTTGGTGCTGGACACCATGATCGAAAACCTACCGCAGGACGCCGAGGCACTGCGCGCCGCCAAGACTGAGCCGCTGGGGATATTGCCACGGCCCAACGAGCTGCCTCGGGGCTGCATCGCGGCAGGCGACCGAGCATTCTTCTGCGACTATGTCCAGGAGTATTTGTCCCACGCCGGGATCAGCAAAGATCGGCTAGCCAAGGGCGGCTACCTCATCCGCACCACTCTTGACCCTAACGTCCAAGCCCCGGTCAAAGCGGCCATCGACAAGTTCGCCAGCCCAAACCTGGCGGGCATCTCCAGTGTGATGAGCGTAATCACCCCGGGCAAAGATGCCCATCGCGTGATCGCGATGGGCAGCAACCGCAGATACGGGCTAGACACCGAGGCCGGTGAAACCATGCGACCACAGACATTTTCCCTGGTCGGCGACGGGGCTGGGTCGGTCTTCAAGATCTTCACCACGGCCGCCGCACTGGACATGGGGATGGGCATCAACGCCAAACTCGAGGTTCCGAGCCGGTTCCAGGCCAAAGGGATGGGAAGCGGCGGAGCCAAGGGGTGCCCTAAGGAAACCTGGTGCGTGATCAACGCCGGTAATTACCGAGGGTCGATGAACGTCACCGACGCCCTAGCCACCTCACCCAACACCGCATTCGCCAAGCTGATCCAGCAAGTCGGGGTGGCGCGCACGGTGGACATGGCGATCAAACTCGGGTTGCGGTCCTATACAACCCCCGGCACAGCCCGCGACTATAATCCGGACAGCAACGAAAGCTTAGCCGACTTCGTAAAACGGCAGAACATCGGTTCGTTCACCCTGGGCCCGATCAAGGTCAACGCGCTGGAGTTATCGAATGTCGCGGCGACGCTGGCATCGGGTGGGATGTGGTGCCCGCCGAACCCAATTGACAAACTGTTCGACCGTAACGGCAACGAAGTTGCCGTTACGGTCGAGACCTGCGATCGGGTGGTGCCCGAGGGTTTGGCCAACACGTTGGCCAACGCAATGAGCAAAGACACAAAGGGCAGCGGCACCGCGGCCGGTTCTGCCGGTGCAGCAGGCTGGGATCTACCAATGTCAGGCAAAACTGGCACCACAGAAGCCCACCGATCCTCCGGCTTCGTAGGTTTCACCAACCACTACGCAGCGGCCAACTATATCTACGACGATTCCACCTCGCCAACGAATCTGTGCTCCGGTCCACTGCGGCACTGCAGCAACGGTGACTTATACGGCGGTAACGAGCCAGCCCGAACCTGGTTCACCGCGATGAAGCCGATCGCCACCAAATTCGGTGAAGTCCGCTTGCCACCGACCGATCCGCGCTACGTCGACGGTTCTCCCGGTTCACAGGTGCCAAGCGTGACCGGACTGGACCTGGACGCGGCGCGCCAGCGCCTGAAGGGGGCAGGTTTCCAGGTTGCCGATCAGCCCACCTTGATCAACAGCACCGCCAAGCTCGGCGCAGTGGTCGGCACCACACCCAGCGGCCAAACAATTCCGGGTTCGATCATTACAATTCAAACCAGCAGCGGCATACCGCCGGCTCCGCCACCGCCGCCGGAAGGCGGCCCGCCGATGCCACCCTCGGTTGGATCGCAGGTCATCGAAATTCCCGGCTTGCCGCCAATCACCATTCCGCTACTAGCGCCTCCGTAAACCCGCA

Protein Sequence 

>ML2308_PonA2_protein
SASQPSSQFSSLRGIAYWPALSPPQ_CSRWPADWG_YPTVLRKW_PTDRPNFSRARCPRYRQWSTRRETRSRGCTRNADSRYPPTRSPTP_SWPSFPSRINALPTTTVWTGRAP_PDWPATHPATWTLAAVRRSSSST_KTISYW_PLKPTPKNVRPSKPPRHASCARSG_RSRWTRRSPNPRS_PAT_TWCRSATTLSACKMQRRPTSASTRPT_IGNKQHYSPAWCNRPARSTRTPTLKARWPGETWCWTP_SKTYRRTPRHCAPPRLSRWGYCHGPTSCLGAASRQATEHSSATMSRSICPTPGSAKIG_PRAATSSAPLLTLTSKPRSKRPSTSSPAQTWRASPV__A_SPRAKMPIA_SRWAATADTG_TPRPVKPCDHRHFPWSATGLGRSSRSSPRPPHWTWGWASTPNSRFRAGSRPKGWEAAEPRGALRKPGA_STPVITEGR_TSPTP_PPHPTPHSPS_SSKSGWRARWTWRSNSGCGPIQPPAQPATIIRTATKA_PTS_NGRTSVRSPWARSRSTRWSYRMSRRRWHRVGCGARRTQLTNCSTVTATKLPLRSRPAIGWCPRVWPTRWPTQ_AKTQRAAAPRPVLPVQQAGIYQCQAKLAPQKPTDPPAS_VSPTTTQRPTISTTIPPRQRICAPVHCGTAATVTYTAVTSQPEPGSPR_SRSPPNSVKSACHRPIRATSTVLPVHRCQA_PDWTWTRRASA_RGQVSRLPISPP_STAPPSSAQWSAPHPAAKQFRVRSLQFKPAAAYRRLRHRRRKAARRCHPRLDRRSSKFPACRQSPFRY_RLRKPA

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding PonA2 with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

3 show intermediate predicted evidence for PPIs

116 show weak predicted evidence for PPIs

View all pooled AlphaFold results for PonA2

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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