leuA
mL2324
2-ISOPROPYLMALATE SYNTHASE LEUA (ALPHA-ISOPROPYLMALATE SYNTHASE) (ALPHA-IPM SYNTHETASE)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 2754647 – 2756470
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL2324_leuA_dna
GCTTTTCTGAGTCTTTGAGCCAGGATCCAGCAGATGCCTATAAATCGGCACCCTCCATCACCAAACCCATGGGCCCGCCCAGTCCCGGCCAACCCCAGTGGAATCCCCAACGAGCTACATCGATGCCAGTCTTCCGGTACCGGCCGTTCGCCAAGGAAGTCGAGCCTATCCGGCTAGTTGACCGCACCTGGCCCGACCGCGTCATTGATTGCGCGCCTCTGTGGTGTGCGGTGGATCTGCGGGACGGCAACCAAGCGCTGATCGACCCGATGAGCCCAATCTGCAAACGCCGCATGTTCGACCTGCTGGTTCGCATGGGCTACAAGGAGATCGAGGTCGGATTCCCGTCGGCCAGCCAGACTGACTTCGACTTCGTCCGCGAGATCATCACCGACGGCACTATTCCGGACGACGTCACCATCCAGGTTCTGACCCAATGCCGACCGGAACTGATTGAGCGCACCTTCGAAGCCTGCGAAAACGCGTCGCGGGTTATAGTGCACTTCTACAACTCAACGTCAATTCTGCAGCGCCGCGTGGTTTTTCGCGCCGACCAAGCCACGGTAAAGGCTATCGCGACCGACGGTGCTCGTAAGTGTGTCGAAGAGGCGTTCAAGTACCCGGGCACGCACTGGCGATTCGAGTATTCACCGGAATCCTATACCGGGACCGAGCTGGAATACGCCAAACAGGTGTGCGACGCCGTCGGTGAAGTCATTCAACCGACACCGGACAACCCGATCATCTTTAACCTGCCTGCCACCGTGGAGATGGCCACCCCCAATGTCTACGCTGACTCGATCGAGTGGATGAGCCGCAATCTGGCCAACCGAGAGTCCGTCATCCTGAGCCTGCATCCACACAACGACCGCGGAACCGCTGTCGCCGCAGCCGAATTGGGCTATCACGCCGGTGCCGACAGAATCGAGGGCTGCCTGTTCGGCAACGGGGAACGCACCGGCAACGTGTGCCTGGTAACGTTGGGACTGAACCTGTTTTCCCGCGGTGTGGATCCCCAGATCGACTTCTCCAATATCGATGAGATCCGGCGAACGGTGGAGTACTGCAACAAGCTGCGGGTGCACGAACGTCACCCCTACGGGGGAGACCTCGTGTACACCGCGTTCTCTGGCAGCCACCAGGATGCCATCAACAAGGGCCTGGACCAGATGAAGATCGATGCGGACGCCGCCGACTCCGATGTCGACGACATCCTGTGGCAAGTACCGTACCTGCCGATCGACCCGCGCGACGTCGGCCGCACCTACGAGGCGGTGATCCGGGTCAACTCGCAGTCTGGTAAGGGCGGCGTGGCTTACATCATGAAGGCCGACCACGGTCTTGAACTGCCGCGACGGCTGCAGATCGAGTTTTCTCGAGCGATCCAGAAAATCAGTGAGGGCGAAGGAGGCGAGATCACACCCACGGAGATGTGGGACGTGTTCTTCGAGGAGTACCTCTCACCGGTGCAGCCGCTGGAACGCATAAAGCAGCGGGTCAATGCCGCAGAGGAAGACGGCGGCAGCACCAGTATTGCCGCTACCGTCAAGATCAACGGTGAAGAGACCGAAATCAGCGGAGTCGGCAACGGCCCACTGGCCGCTTTCATCGACGCACTGGGCCACGTCGGCTTGCAGGTAGCCGTTCTGGATTATTCCGAACACGCGATGAACGCCGGCGACGACGCGCAGGCTGCTGCTTACGTCGAGGCATCGGTACATGGGCACACAGCATGGGGTGTGGGCATTGCACCGTCGATCACCACAGCGTCGCTACGTGCCGTCGTCTCAGCGGTCAACAGGGCAATGCCCCGCTAGGACTTTA

Protein Sequence 

>ML2324_LeuA_protein
AFLSL_ARIQQMPINRHPPSPNPWARPVPANPSGIPNELHRCQSSGTGRSPRKSSLSG_LTAPGPTASLIARLCGVRWICGTATKR_STR_AQSANAACSTCWFAWATRRSRSDSRRPARLTSTSSARSSPTALFRTTSPSRF_PNADRN_LSAPSKPAKTRRGL_CTSTTQRQFCSAAWFFAPTKPR_RLSRPTVLVSVSKRRSSTRARTGDSSIHRNPIPGPSWNTPNRCATPSVKSFNRHRTTRSSLTCLPPWRWPPPMSTLTRSSG_AAIWPTESPSS_ACIHTTTAEPLSPQPNWAITPVPTESRAACSATGNAPATCAW_RWD_TCFPAVWIPRSTSPISMRSGERWSTATSCGCTNVTPTGETSCTPRSLAATRMPSTRAWTR_RSMRTPPTPMSTTSCGKYRTCRSTRATSAAPTRR_SGSTRSLVRAAWLTS_RPTTVLNCRDGCRSSFLERSRKSVRAKEARSHPRRCGTCSSRSTSHRCSRWNA_SSGSMPQRKTAAAPVLPLPSRSTVKRPKSAESATAHWPLSSTHWATSACR_PFWIIPNTR_TPATTRRLLLTSRHRYMGTQHGVWALHRRSPQRRYVPSSQRSTGQCPARTL

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding LeuA with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

0 show intermediate predicted evidence for PPIs

7 show weak predicted evidence for PPIs

View all pooled AlphaFold results for LeuA

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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