ppsC
mL2355c
PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 2804876 – 2811481
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL2355c_ppsC_dna
GAACGCAATGACCGCCTCGACACCTGATCGCCGGGCGATCATCACCGAGGCGTTGCACAAGATCGATGATCTCACTGCACGCCTGGAAATCGCCGAAAAGTCCAGCACTGAGCCGATCGCAGTGATCGGCATGGGGTGCCGATTCCCGGGCGGGGTCAACAACCCCGAACAGTTCTGGGATCTGTTGTGCGATGGCCGAAGCGGCATCGTTCGGGTTCCTTCCGACCGATGGGATGCCGATGCCTACTATACGGACGATCACACCGTGCCGGGCACGATATGCAGCACCGAAGGCGGTTTTCTCACCGGCTGGCAGCCTGATGAGTTCGATGCGGAGTTCTTCTCAATTTCCCCGCGCGAAGCATCGGCAATGGACCCGCAGCAGCGGTTGTTGATTGAGGTCGCTTGGGAAGCGTTGGAAGACGCGGGTGTCGCGCCGCACACCATTCGTGGGACTCAAACCTCGGTATTCGTCGGTGTTACCGCTTACGATTATATGCTCACGTTGGCGGGCCGGTTGCGTCCCGAAGATCTCGACGCCTACATACCAACCGGAAATTCGGCGAACTTTGCTGCTGGACGGTTGGCCTATATCCTCGGGGTTCGTGGACCGGCCGTGGTCATCGACACGGCTTGCTCGTCGTCGTTGGTGGCGGTGCACCTGGCGTGTCAGAGCTTGCGTCACCGAGAAAGCGACGCGGCTTTGGTGGGTGGAACCAATTTGTTGCTTAGCCCGGGACCGAGCATTGCATGCTCGCGTTGGGGGATGCTATCTCCGGCGGGGCAATGCAAGGCCTTCGATGTGTCCGCCGACGGGTATGTGCGTGGCGAGGGTGCCGGGGTGGTGGTGCTTAAGCGGTTGGATGACGCGGTGCGCGACGGCAACCGTATCCTCGCCATAGTGCGTGGCTCGGCGGTCAACCAGGACGGCGCCAGCAGCGGAGTGACCGTTCCCAACGGGCCGGCGCAGCAGGAGTTGTTGCGCACCGCGTTAGCGTCGTCGAAGTTGACGGCTGCTGACATTGACTACATCGAGGCCCATGGAACGGGAACGCCGTTGGGTGATCCGATCGAACTCGACTCGCTGAGCAAGGTTTTCAGCGATCGGCAGAGCCGGCGGGGCTCTGTCCCGTTGGTGATTGGGTCGGTGAAGACTAACCTCGGCCATCTGGAAGCGGCAGCTGGGATCGCTGGGTTCATCAAGGCGGTGCTGGCTGTGCAACGTGGTTTCATTCCGCGGCACCTCAACTTCCACCAGTTGACAACACATGCCAGTGAGGCTGCATCGCGGCTAAACATTGCGTCCGAAGGCCTCGAATGGCCGACTGTCGGTCGGCCGCGCCGGGCGGGGGTGTCGTCGTTCGGCGTCAGCGGGACGAATGCACATGTGGTGCTCGAGCAAGCACCGGACCCGGTAGCAGTGCCAGCACCTGGGCCGGCGCTGCGCCTTGTTCCTGCGGTGTCGACACTGGTGGTGTCGGGTAAGACAGTGCAGCGGGTGGCCGCGACAGCATCGGTGCTGGCTGATTGGATGGAAGGCCCTGGAGCTGCGGTGCCGCTGACTGACGTTGCGCACACCCTGAACCACCACCGGGCCCGGCACACCAAATTCGGCACTGTGGCGGCCGTTGATCGGGGCCAAGCGGTGGCGGGGTTGCGTGCGCTGGCCGCGGGTCAATCCACCTCCGGTGTGGTGGCCCCCCGTGACAGCGTTGTTGGTCCGGGCACTGTGTTCGTCTATTCGGGCCGAGGATCGCAGTGGGCCGGAATGGGTCGCCAACTGATGGCCGACGAGCCGGCATTCGCCGAAGCTATTGCCAAACTAGAGCACGAATTTGTTGTACAGGCAGGTTTTTCGTTGCACGAGGTAATCGCCAACGGCAAGGAGCTCGTAGGCATCGAACAGATCCAGCTGGGACTGATGGGAATGCAGCTGGCGCTGACCGAGTTGTGGCGCTCCTACGGGGTAGAACCCGATGCGGTGATCGGTCACTCTATGGGCGAAGTCGCCGCCGCGGTAGTGGCCGGGGCTCTGACTCCTACCCAGGGTTTACGGGTCACTGCGACCCGATCGCGGCTAATGGCGCCATTGTCCGGTCAGGGCACAATGGCGTTGCTCGAACTCGACGCCGTGGCCACTGAGGCGTTGATCGCCGACTATCCGCAGGTGAGCTTGGGGATCTATGCTTCCCCGCGCCAAACTGTGATTGCCGGGCCGACGGCCATGATCGATGCTCTGATTGACAAGGTGCGCCAGCAGGACGGTTTTGCCACCCGAGTCAACATCGAGGTGGCACCGCACAACCCAGCCATGGATGCGCTGCAACCTCAGATGCGTTCGGAGCTAGCCGATCTCACTCCGCAGCAACCAACCATCCCGATCATCTCTACCACATACGAGGACTTCGGCAGCACCCCTGTCTTCGACGTCGAGCACTGGGCGACTAACATGCGTAATCCTGTGCGTTTTCAGCAGGCCATTACTCACGCTAGTAGCGGTGTCGGCGGCGACTATCACACCTTCATTGAGATCAGCGCACACCCACTGCTCACTCATTCGATCAGTGACATTCTGTGCAGCATCGCCGGCACAGCCGAAGAAAATGCTGTCGGTGCGGGCTATTTGAGCATCGGCACCCTACAACGCGATGCTCACGACACACTCGAGTTCCACACCAACCTCAACGCTACGCATACCAGCCGCCCTCCCCGAACTCCTCATCCGCCCGAACCGCACCCGGTGCTGCCCATCACTCCGTGGCAGCACACTCGCCATTGGATCAGTGCCATGTCGGCGGCATACCACAGGGCAGACACTCATCCTCTGCTTGGCGTTGGTGTTACCGATCCCACCAGTGGCACCAGAGTATGGGAAAGCCAATTGGGCCCTGATCTGCTGTGGCTGGGGGATCACGTTATTGACGATCTCTGCGTATTGCCGGGTGCAGCCTACGCCGAGGTTGCGTTGGCGGCCGCGACGGACACCTTTCCAAACGAGCGAGTCGAAGGAGATCAGCCGTGGATGATCTATGAGCTTGACCTTCATCAGGTTTTGCACGTGACCGAAGGCACTGTTCTCGTTACCACGCTCACCGGCGACCAGCAGCGGTGCCGGATTGAAATGCGCACTCGCAACGGTTTTTCGGGTTGGACCACTCATGCCACTGCCACTGTTGGTCCTGCCGAGTCAGTGCAACCGTCAGATCGCGAGGAGCGCACCGCAACCCCGGTCGATGTGGTGGATGAACTGGGCCCCGAAGACTTGTATCAGCGGCTGTGCAGCGCCGGTCAACAGCATGGTCCGGCGTTTCAAGGGATCGTCGGGCTTGCGGTTGAAGAATCTGGTGCCGCCCGCGCTGAGGTGCGGTTGCCTTCGTCGGCCAGAATGGGTTTCCGCGACTTCTTGCTGCACCCGGTAATGATGGATATTGCGTTACAGACACTGGGTGCTACCCGGATGGCGACCGATTTAGCCGGAGGGCCGACCGCCCGGAAAACATTGGTCCTACCAGTACGTTTTGCGGGCGTGCATGTGTACGGTGATGTCACTCGCGGTGTCTGTGCTGTCGGGTTGCTGACCGCAACCGAGGGCTTGGATCGGCTGGTTGGCGAAGTTGTCCTGACTGATCTGGACGGGCAACCGCTACTTGTCATCGACGAAGTCCAGATGACGGTGCTTGGAGCCGGCAGCGACGCAACGGAACTCACCGATCGCCTATTCACGTTGGAGTGGGAACCTACACCGCTGTATAAGGAGGTTTCGAGATCTTCCGCGCAAGGTGGCTTGTTGTTGATCGGTGACGTCGCCGCGGGTGACCCGCTGTTGCTTGCCTTACAGTCGTCGCTGCGCGCCCGATTGAGTGAAAATGGGCCTCCACCAGTGGATTGCGTCTCCTTTAGCGACGAAGTGAAGCTGCAGGCGGCGATCACTCGAACCGACATCAGCTGGGATGGCATCGTCGTGGTGTGTCCGCCGCGAGCGAGCGATGAGTCTTTGCCCGATGATGCTCAACTGGAACTAGCGCAGACGCGCACACTTCAGATCGCCGGCGTGGTTCAAGCAGTGACGCAAATGGGTGCTCGCAAGAGTCCACGGCTGTGGATCGTCACCCGAGGTGCGCAGCAGCTTAACGCAGGCGAGTCAGTAACGTTGGCGCAGACTGAGCTACGTGGAATTGTCCGAGTGCTGACGTTCGAGCATTCGGAACTCAAAGCGACCCTGCTTGACATTGAAGCTGACGGCACCGACTCACTTGACGACCTGACCGAGGAGCTGCTGGCCGGCTCGAACCACGACGAGGTCGCCTACCGGGACGGACAACGTTATGTCAACCGGTTGGTGCCGGCTCCCATCACGCCGAAAGGCGAACTTGCCGGCGAAACTCGTCGCAAGGTTGTAGAACTGGGTGGCTTAGGTGCTGTCCAGCTGCAGATCGATCAACCCGGACGACTGGACGCATTGACGGTGCACCAAGTCAAGCGGGGCGAGCCGGAAGGCGATCAGGTCGAGGTTCGTGTCGTCGCTGCGGGACTCAATTTCAGCGATGTGCTCAAGGCGATGGGTGTGTACCCGGGACTCGACGGTGGAGCACCGGCGATCGGTGGCGAGTGTGTCGGCTACGTGACAGCCATAGGAGACGACGTTGACTCTGTCGAGGTTGGTCAGCGTGTTATCGCCTTTGGCCCCGGCACATTCGGAACATACGTGGGTACGATTGCCGATCTCGTCGTCCCAATCCCCGACACCTTATCCGATCACGAGGCAGCCACGTTCGGCGTAGCGTACCTCACCGCCTGGCACTGCCTGTGCGAGGTTGGGCGGCTGTCTCCCGGTGAACGTGTGCTGATCCATTCCGCCACTGGTGGTGTCGGCATGGCTGCGGTTTCGATCGCCAAGATGCTCGGTGCCCGCATCTACACAACGGCCGGTTCGGATGCCAAGCGACAAATGCTGTCCGAGCTCGGTGTCGAGTATGTCGGTGACTCGCGAAGTGTGGACTTCGCCGACGAGATACTCGAGCTCACGCACGGTTATGGCGTCGATATCATTCTCAATTCTCTTGCAGATAAAGCGATTCAGCGCGGTGTGCAGATACTTGCTCCCGGTGGAAGGTTCATCGAAATCGGCAAGAAAGATGTCTACGACGATGCCAACCTGGGCTTGGCCGCGCTGGCAAAGAGTGCTTCCTTCTCCGTAGTAGACCTTGATTTGAATCTGAAACTGCATCCTGCCCGGTATCGCCAACTGCTGCAACACATCTTGGCGCACGTGGCCGATGGTAGATTGCCGGTGCTTCCTGTCACTGAATTCAGTCTGCACAACGCTGCCGATGCATTTCGGCTCATGGCCTCCGGCAAGCATACCGGCAAGATCGTCATATCAATACCGTATGAGGGCAACATTGAAGCGATCGCGTCCCCGCCACCCGTTCCATTGGTCAGCCAAGACGGCGGTTACCTGGTCGTTGGCGGTATGGGCGGTCTTGGCTTCGTCTTCGCGCGATGGCTGGCCGAGCAAGGAGCGGGATTGATTGTCTTGAACGGACGTTCGTCCCCCAGCGATGATGTTACGGCGGCCATAGCGGACTTGACCGCAGCGGGCCACCGGATTGAGGTGGTCACGGGCGACATCTCTGAACCCGGTACGGCGGACCGACTGGTGCATGCGGTCCAAAGCGCAGGCTTCCGGCTGGCCGGAGTCCTGCACAGCGCCATGGTTCTCGCTGACGAGATCATGCTGAATATGACGGATTCTGCGGCGAGGCGGGTGTTCGTTCCCAAAGTCACCGGCAGCTGGCGGTTACATCAGGCCACCGCTGCGTTCGAAGTCGATTGGTGGTTGACCTTCTCCTCGGCTTCCTCGCTGCTCGGTACACCAGGGCAGGGTGCGTATGCCGCCGCGAACGCGTGGGTCGACGGCCTGGTAGCCTATCGGCGTTCGCTTGGACTACCCGCCGTCGGAATCAACTGGGGCCCATGGGCTGAGGTGGGGCGTGCCCAATTCTTCGCTGGTCTCGGTGTTTCGCTGCTCACCGCCGAGCAGGGTCTGGCGGCGATGCAGACGGTGCTTGCCGCTGATCGTGCGCAAACTGGTGTGTTCAGCCTCGATGCGCGGCAGTGGTTCCAATCTTTCCCGGCTGTGGCGGGTTCGTCGTTGTTCGCAAATTTGCGCGACACGGCAACCCTGAAAAGCGGGGAGCGGCGCGGCGTGGGCAAGATCCGTGCGCAACTGGACGTTCTCGACGCAGCCGAGCGCCCGGGACACCTCGCGTCGGCGATCGCCGACGAGATCAGAGCGGTGCTACGCTCGAGCGATCCAATCGACCACGACCGGCCGCTGGAAGCGCTGGGTCTTGATTCCTTGATGGGCCTGGAATTGCGAAACCGGTTGGAAGCCAGTCTGGGCATCACGTTGCCTGTCGCGCTGGTATGGGCATATCCGACAACTGCTGACCTTGCGGCCGCACTATGCGAACGAATGGACTATGCGTTACCGGCCGAGGTGCAGGAGGCGACTGACACAAACGCGGAACTGTCCAAAGCGGAGATGGACCTGCTCTCTGATCTGGTCGAAGCCAGCGAGCTGGAAGCTGCAACGAGAGGCGA

Protein Sequence 

>ML2355c_PpsC_protein
ERNDRLDT_SPGDHHRGVAQDR_SHCTPGNRRKVQH_ADRSDRHGVPIPGRGQQPRTVLGSVVRWPKRHRSGSFRPMGCRCLLYGRSHRAGHDMQHRRRFSHRLAA__VRCGVLLNFPARSIGNGPAAAVVD_GRLGSVGRRGCRAAHHSWDSNLGIRRCYRLRLYAHVGGPVASRRSRRLHTNRKFGELCCWTVGLYPRGSWTGRGHRHGLLVVVGGGAPGVSELASPRKRRGFGGWNQFVA_PGTEHCMLALGDAISGGAMQGLRCVRRRVCAWRGCRGGGA_AVG_RGARRQPYPRHSAWLGGQPGRRQQRSDRSQRAGAAGVVAHRVSVVEVDGC_H_LHRGPWNGNAVG_SDRTRLAEQGFQRSAEPAGLCPVGDWVGED_PRPSGSGSWDRWVHQGGAGCATWFHSAAPQLPPVDNTCQ_GCIAAKHCVRRPRMADCRSAAPGGGVVVRRQRDECTCGARASTGPGSSASTWAGAAPCSCGVDTGGVG_DSAAGGRDSIGAG_LDGRPWSCGAAD_RCAHPEPPPGPAHQIRHCGGR_SGPSGGGVACAGRGSIHLRCGGPP_QRCWSGHCVRLFGPRIAVGRNGSPTDGRRAGIRRSYCQTRARICCTGRFFVARGNRQRQGARRHRTDPAGTDGNAAGADRVVALLRGRTRCGDRSLYGRSRRRGSGRGSDSYPGFTGHCDPIAANGAIVRSGHNGVARTRRRGH_GVDRRLSAGELGDLCFPAPNCDCRADGHDRCSD_QGAPAGRFCHPSQHRGGTAQPSHGCAATSDAFGASRSHSAATNHPDHLYHIRGLRQHPCLRRRALGD_HA_SCAFSAGHYSR__RCRRRLSHLH_DQRTPTAHSFDQ_HSVQHRRHSRRKCCRCGLFEHRHPTTRCSRHTRVPHQPQRYAYQPPSPNSSSARTAPGAAHHSVAAHSPLDQCHVGGIPQGRHSSSAWRWCYRSHQWHQSMGKPIGP_SAVAGGSRY_RSLRIAGCSLRRGCVGGRDGHLSKRASRRRSAVDDL_A_PSSGFARDRRHCSRYHAHRRPAAVPD_NAHSQRFFGLDHSCHCHCWSCRVSATVRSRGAHRNPGRCGG_TGPRRLVSAAVQRRSTAWSGVSRDRRACG_RIWCRPR_GAVAFVGQNGFPRLLAAPGNDGYCVTDTGCYPDGDRFSRRADRPENIGPTSTFCGRACVR_CHSRCLCCRVADRNRGLGSAGWRSCPD_SGRATATCHRRSPDDGAWSRQRRNGTHRSPIHVGVGTYTAV_GGFEIFRARWLVVDR_RRRG_PAVACLTVVAARPIE_KWASTSGLRLL_RRSEAAGGDHSNRHQLGWHRRGVSAASER_VFAR_CSTGTSADAHTSDRRRGSSSDANGCSQESTAVDRHPRCAAA_RRRVSNVGAD_ATWNCPSADVRAFGTQSDPA_H_S_RHRLT_RPDRGAAGRLEPRRGRLPGRTTLCQPVGAGSHHAERRTCRRNSSQGCRTGWLRCCPAADRSTRTTGRIDGAPSQAGRAGRRSGRGSCRRCGTQFQRCAQGDGCVPGTRRWSTGDRWRVCRLRDSHRRRR_LCRGWSACYRLWPRHIRNIRGYDCRSRRPNPRHLIRSRGSHVRRSVPHRLALPVRGWAAVSR_TCADPFRHWWCRHGCGFDRQDARCPHLHNGRFGCQATNAVRARCRVCR_LAKCGLRRRDTRAHARLWRRYHSQFSCR_SDSARCADTCSRWKVHRNRQERCLRRCQPGLGRAGKECFLLRSRP_FESETASCPVSPTAATHLGARGRW_IAGASCH_IQSAQRCRCISAHGLRQAYRQDRHINTV_GQH_SDRVPATRSIGQPRRRLPGRWRYGRSWLRLRAMAGRARSGIDCLERTFVPQR_CYGGHSGLDRSGPPD_GGHGRHL_TRYGGPTGACGPKRRLPAGRSPAQRHGSR_RDHAEYDGFCGEAGVRSQSHRQLAVTSGHRCVRSRLVVDLLLGFLAARYTRAGCVCRRERVGRRPGSLSAFAWTTRRRNQLGPMG_GGACPILRWSRCFAAHRRAGSGGDADGACR_SCANWCVQPRCAAVVPIFPGCGGFVVVRKFARHGNPEKRGAARRGQDPCATGRSRRSRAPGTPRVGDRRRDQSGATLERSNRPRPAAGSAGS_FLDGPGIAKPVGSQSGHHVACRAGMGISDNC_PCGRTMRTNGLCVTGRGAGGD_HKRGTVQSGDGPAL_SGRSQRAGSCNERR

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding PpsC with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

13 show intermediate predicted evidence for PPIs

29 show weak predicted evidence for PPIs

View all pooled AlphaFold results for PpsC

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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