ppsA
mL2357c
PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 2816101 – 2821716
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL2357c_ppsA_dna
TGACGGTATGACGGCGAGCATTGGTAGCGAAGCTGACCTTTGCCACTGGCTAGTCAACTACTTGGTGACTAATATCGGCTGCACACCGGATGAAGTCGATCTTAATCTATCGTTGACCGACTTGGGTATGAGCTCCCGTGATGCAGTTGTGCTCTCCGGGGAATTGACCGATTTGTTGGGTAAGACCGTATCCCCGATTGACTTCTGGGAGCATCCGACGATCAACGCGCTGGCCGCCTATCTCATTGCTCCCGCACCTGACCCCGAATCAGAATCGGCGCCACGGCGCTCGGTCCAGGGTGCACTCGAGGAGCCGATCGCTGTCATCGGGATGGGGTGTCGTTTCCCAGGGGGGATATCTGGTCCAGAAGCGTTGTGGCAGTTTCTGTGTGACCGTCGTTCCTCCATCGGACAGGTTCCCAATGAACGGTGGGAGCTCTTCGACGACGGCTCGCCGGAAGTAAAAGCACTGCTCGCCCGTACTACGCGGTGGGGGTCATTCTTGGAGGATATTGACGCCTTTGACTCGGAATTTTTCGAGATCTCACCCAGCGAGGCTGACAAGATGGATCCGCAGCAGCGCCTTCTGCTGGAAGTGGCTTGGGAGGCGTTGGAGCACGCGGGAATTTCGTCCAACTCGCTGCGTCGTTCGCAAACAGGAGTATTCGCCGGATCGTGCCTGAGCGAATATGGTGCTATCGCTTCCACCGATCTCTCCCAAGTGGATGGCTGGAGCAACACGGGTGGCGCGATGAGCATCATAGCGAACCGCCTTTCGTATTTCCTCGACTTACGTGGTCCATCGGTGGCGGTTGATACGGCGTGCTCGTCGTCGTTGGTAGCGATCCACTTAGCCTGCCAAAGCCTGCGGACCGCGGATGCCAACCTGGCTATTGCGGCGGGCGTGAATTTGCTATTGTCTCCGGCCGTATTTCGTGGCTTCGACCAGGTCGGGGCGTTGTCGCCTACCGGTTGTTGCCGCGCGTTCGATGCTGCGGCGGACGGGTTTGTGCGCGGTGAAGGTGCTGGCGTAGTGGTGCTTAAACGGTTGACCGATGCGCAGCGCGACGGTGATCGGGTGCTTGCCATTATCCGCGGTTCTGCTGTCAATCAGGATGGCCGCTCCAACGGGCTGATGGCTCCTAACCCGGCGGCCCAAGTAGCGGTTCTGCGCACCGCGTATGCCAACGCAGCAATGCCACCGACTGCCATTGACTACGTCGAAACTCATGGGACCGGGACTCTGTTGGGAGATCCGATAGAAGCGCGCGCTTTGGGTGCGGTGCTGGGTCGGGGACGTGCCGAGGATTCTCCGCTACTGATCGGGGCTGTTAAGACTAACCTGGGTCACTTGGAGGCTGCTGCGGGCATCGCCGGCTTCATCAAGACAGTGTTGGCGGTGCAGCGTGGCCAGATTCCACCGAATCAGCGTTTTGAAAGCCCGAACCTGCATATTCCTTTTGCTGAGTTGCGTATGAAAGTTGTTGATAAGCATATGGAATGGCCGGATACAGGGCATCTGCGGCGCGCGGCGGTGTCATCGTTTGGCTTCGGTGGGACGAACGCGCATGTTGTCATTGAGCAGGGTCCTGAGCTGACACCGGTCACAGAATGCAGTTCCAACACTGCGGTGTCGACGTTGGTGGTGACGGGTAAGACGGCGTCGCGGGTGGCAGCGATGGCGGGGATGCTGGCCGATTGGGTTGAGGGGCCCGGTGCTGAAGTGGCGTTGGCTGATGTGGCCCATACATTGAATCATCACCGGTCGCGGCACGCCAAGTTCGGCACCGTGGTTGCCCGTGATCGGATCCAGGCAGTGGCTGGATTGCGGGCGTTGGCCGCCGGCAAACAGGCGCCCGGTGTGGTCGGGCAGCAGGATGGCACACCTGGGTCAGGAACGGTGTTTGTGTACTCGGGACGTGGTTCGCAGTGGGCGGGGATGGGGCGTCAATTGCTGGCCGATGAACCGGCTTTCACGGCCGCGGTTGCCGAGTTGGAACCGGTGTTTGTTGTCCACGCCGGTTTCTCGTTGCACGATGTGCTCGCTAATGGCAAAGAACTGGTTGGTATCGAGCAGATCCAGCTGGGGTTAATCGGCATGCAACTGACGCTGACTGAGTTGTGGCGTTCCTATGGGGTGCAACCTGATTTGGTGATCGGGCATTCGCTGGGTGAGGTGGCCGCCGCCGTGGTGGCTGGGGCGCTTACCGCCGCTGAGGGGCTGCGGGTGACAGCCACTCGGTCGCGGCTGATGGCCCCGCTGTCTGGGCAGGGCGGTATGGCACTGCTCGAACTCGACGCGGTCGAGACGGAGGCGTTGATTGTCGACTACTCGCAGGTGACATTGGCGATTTACAATTCGCCGCGCCAAACGGTGATTGCCGGGCCCACTGAACAGATCGATGAGTTGATTGACCGGGTGCGCGCGCAGAATCGGTTTGCCAGTCGGGTCAATATTGAAGTGGCCCCCCACAATCCGGCGATGGATGCGCTGCAGCCGCAGATGCGTTCCGAGCTCGCCGATGTGGCCCCACGGACTCCGACGATTCCGATCCTTTCCACCACCTATGCTGACCTTGGCTCGTGCCCGGTGTTCGATGCCCAGCACTGGGCCACCAACATGCGCAACCCAGTGCATTTCCAGCAGGCCATCATGACCGCTGGAACTGACCACCGCACTTTCATCGAAATCAGTGCACACCCGCTGCTGACCCAAGCCATTACTGACACCCTGCACGGTACCCGGTGCATCAGCATTGGGACCCTGCAACGCGATGCCGACGACACCGTCACCTTTCACACCAACCTCAACAACGTCCACACCGTCCACCCACCACACACCCCTCATCCTGCGGAACCACACGTAACTATCCCCAGCACTCCCTGGCAGCACACCCGCCACTGGATCCCTCGGAAACGTTCGGTCAACTCTATTGGATTGGCACCCCAGGTGGGCACGCTACTTGGCCAACACACCGCGGTCTCAGGGATTCTTCCTATCCACTTGTGGCAGGCGCGGCTAGCGCCGCAGGCCAAGCCGTACAGGGGTTGGCATCGAGTCCACGGTGTCGAGGTGGTCCCTGCTTCTATTGTGCTGCGCACAATCCTTTGTGCTGCAGCAGAATTGGGTTATTCTACGCTATTCGAGATCCGATTCGAGCAACCCATTTTCGCTAATCTCCCCCGTTTGATCCAAGTCGTCGTCGATAACCAATTGATCAGCCTGGCCTCAAGTCCGGCCACCGAAACTCCTCAGCACCGGTGGACGCGGCATGTGACCGCGCAGCTTTCCTCAGCATCGGCGCGTTCCGCGGTTCCATCGGACCACCCGGATCAGATTAATGGTCATCTTGAGGTGATTTCGGACCCGATTCCCGACGTAGCTTCGCTGCTCGCGCTGTGTGGGGTTGACGGCCTGCCTTTCGAGTGGTCCGTCAAGTCATGGGCGAAAAAGACGCAGCAGTCAACCAGCCGCACGGTTGAGATCGAATTTCCCGATACCCTGCCCGACGGGGCGATCGCGCCGCTACTCGACGCCGCAATTCTTATCCCAGCGCTGGCGGACGTTACCGAAACGCAATTTTACGTGCCGGCAAGCATTAAGCAGGTGTGGTTAGGCGACACCGCTACAGGACCATGTGGTGCGGTGACGCTAAATCGCACTGCTTGCGACGACGACGGGATTACCGTCGATGTCACCGTCGCCGACGGCAGCGGTGTGCCGTTGGCGTTGATGCGGTCACTTCGGTATCGAGCGTTAGACCTTGACAACGCGCAACAGGACTATTCGACTGTTTTCGTTGAATCCCATGTGGATGCCCTTACAGATGCCAGGAATTTCGTGCATGCGATCGATTGGCAACCGCGGACCGACCTGGATTGCTCCAACACCCCGGTAGCCAGTTCGGGGTCTGTCGCGGTAATCGGTGATGCTCGCGCTGGGTTTGGCTTGCTGCTCAAGGAGGCGGGCTATACGTTGGCTGCGCCTGCTGATGGGGTGTCTGAGGTACGTTACGTTGTTTATGTCGCGGATCCCCACCCGGCAACCACTGCCGAGACCGACGTCGACTTTGCCGTGCGAATCACTGCTGAGATCAGCGATTTGGTGAGGGCTTTGGCGAAGCGGGAGCCGGGCAAGCCTGTAGCACTGTGGATCGTCACACGCGGAGTTTACGAATCGGTGGCCTCGTCCGCGTTACGCCAGAGCTTCCTGTGGGGTTTTGGGGGCGTCATCGCCGCGGAGCATCCTGAGATGTGGGGTGGACTCGTCGATCTTGCGGCTAGTGCTCTTGGAGCCGATCGCGACGACATTCTCGACCAATTTGGGCCGACGCTTGCCAGTCTGCTTCAAACACCGACCAGGTCGATCGTGGTATTACGTGACGGCGTCGTGCTTGCCCCGACATTGGTGCCGATCCGAAGTGAGCCGGTGCGCAAATCTTTGCAATGCAAGTCCGATGGGGCCTACCTCATCACCGGCGGAATGGGTGCACTTGGTCTGCTGATGGCTGATTGGCTCGCTGACCGCGGCGCTCGTCGACTGGTGTTGATGGGCCGTACACCGTTACCGCCAAGGCGGGACTGGGAACTCGACACTCTCGATGCCGGACTGCGTCAGAAGATCGATGCTATTTGCGCCCTTGAGATGCGGGGAGTGACAGTCGAAGCCGTCGCGGTTGACGTCGGACACCACGACGATGTGCAGGCCTTGTTGGCCAAGCGTGACCGTGACGGCGCCGCGCCGATCCGGGGGATCATTCATGCGGCAGGCGTTACGAATGACCAACTAGTGACGAACATGACCGACGATCCGGTTCGTCAAGTTATGTGGCCTAAGATCGCCGGCTGCCAGGTGCTGCACGAGGCCTTTCCACCTGGCAGTGTGGACTTTTTCTACTTGACCTCCTCGGCCGCAGGAATATTCGGCATCCCGGGTCAGGGCTCTTACGCTGCCGCCAATTCCTACCTGGACGCGTTGGCGCGTACGCGTCGCCAGCAGGGCTGCCACACTATGAGCATCGACTGGGTAGCCTGGCGCGGGCTCGGATTCGCCGCTAACGCGCAGATTGTCAGTGATGAGTTGCAGCGAATGGGGTCGCGTGATATCACGCCTTCGGAAGCGTTCACCGCGTGGGAGTACGTCGATGCCTACGACGTTGCACAGGCGGTTGTATTGCCGGTCCCTAGGTCCTACGGGTCCGCCGGATCGACTGCCGGGGATAGCTATCTAGTCCCGGCACGAAATTGGTCGCAGATGGAGGCCGCCGAGGTACGGAAGGAGCTTGAAAGTGGCTTACGGACCATCATCGCCGCAGAGCTCCGGGTGGCCGAGGCGGAGCTGGATACAGATCGACCATTCGCCGAACTTGGACTCAACTCCCTTATGGCAATGGCGATTCGGCGTGAAGCCGAGCAATTCATTGGTATAGAGCTGTCGGCAATCATGCTGTTCAACCATCCAACCGTTGCGTTACTAGCCGCGTATCTGACAAAAGTTGTCGCACCGCAGCACGATTCGCAAGGAGACGAGATGGCCGCCTTATCCGCCTCGGCAGGAGGCGTATTAGATAGTCTCTTCGACCGCATCGAATCGACATCGACTGAGGCCGAAGGGTT

Protein Sequence 

>ML2357c_PpsA_protein
RYDGEHW_RS_PLPLASQLLGD_YRLHTG_SRS_SIVDRLGYELP_CSCALRGIDRFVG_DRIPD_LLGASDDQRAGRLSHCSRT_PRIRIGATALGPGCTRGADRCHRDGVSFPRGDIWSRSVVAVSV_PSFLHRTGSQ_TVGALRRRLAGSKSTARPYYAVGVILGGY_RL_LGIFRDLTQRG_QDGSAAAPSAGSGLGGVGARGNFVQLAASFANRSIRRIVPERIWCYRFHRSLPSGWLEQHGWRDEHHSEPPFVFPRLTWSIGGG_YGVLVVVGSDPLSLPKPADRGCQPGYCGGREFAIVSGRISWLRPGRGVVAYRLLPRVRCCGGRVCAR_RCWRSGA_TVDRCAARR_SGACHYPRFCCQSGWPLQRADGS_PGGPSSGSAHRVCQRSNATDCH_LRRNSWDRDSVGRSDRSARFGCGAGSGTCRGFSATDRGC_D_PGSLGGCCGHRRLHQDSVGGAAWPDSTESAF_KPEPAYSFC_VAYESC__AYGMAGYRASAARGGVIVWLRWDERACCH_AGS_ADTGHRMQFQHCGVDVGGDG_DGVAGGSDGGDAGRLG_GARC_SGVG_CGPYIESSPVAARQVRHRGCP_SDPGSGWIAGVGRRQTGARCGRAAGWHTWVRNGVCVLGTWFAVGGDGASIAGR_TGFHGRGCRVGTGVCCPRRFLVARCAR_WQRTGWYRADPAGVNRHATDAD_VVAFLWGAT_FGDRAFAG_GGRRRGGWGAYRR_GAAGDSHSVAADGPAVWAGRYGTARTRRGRDGGVDCRLLAGDIGDLQFAAPNGDCRAH_TDR_VD_PGARAESVCQSGQY_SGPPQSGDGCAAAADAFRARRCGPTDSDDSDPFHHLC_PWLVPGVRCPALGHQHAQPSAFPAGHHDRWN_PPHFHRNQCTPAADPSHY_HPARYPVHQHWDPATRCRRHRHLSHQPQQRPHRPPTTHPSSCGTTRNYPQHSLAAHPPLDPSETFGQLYWIGTPGGHATWPTHRGLRDSSYPLVAGAASAAGQAVQGLASSPRCRGGPCFYCAAHNPLCCSRIGLFYAIRDPIRATHFR_SPPFDPSRRR_PIDQPGLKSGHRNSSAPVDAACDRAAFLSIGAFRGSIGPPGSD_WSS_GDFGPDSRRSFAARAVWG_RPAFRVVRQVMGEKDAAVNQPHG_DRISRYPARRGDRAATRRRNSYPSAGGRYRNAILRAGKH_AGVVRRHRYRTMWCGDAKSHCLRRRRDYRRCHRRRRQRCAVGVDAVTSVSSVRP_QRATGLFDCFR_IPCGCPYRCQEFRACDRLATADRPGLLQHPGSQFGVCRGNR_CSRWVWLAAQGGGLYVGCAC_WGV_GTLRCLCRGSPPGNHCRDRRRLCRANHC_DQRFGEGFGEAGAGQACSTVDRHTRSLRIGGLVRVTPELPVGFWGRHRRGAS_DVGWTRRSCG_CSWSRSRRHSRPIWADACQSASNTDQVDRGIT_RRRACPDIGADPK_AGAQIFAMQVRWGLPHHRRNGCTWSADG_LAR_PRRSSTGVDGPYTVTAKAGLGTRHSRCRTASEDRCYLRP_DAGSDSRSRRG_RRTPRRCAGLVGQA_P_RRRADPGDHSCGRRYE_PTSDEHDRRSGSSSYVA_DRRLPGAARGLSTWQCGLFLLDLLGRRNIRHPGSGLLRCRQFLPGRVGAYASPAGLPHYEHRLGSLARARIRR_RADCQ__VAANGVA_YHAFGSVHRVGVRRCLRRCTGGCIAGP_VLRVRRIDCRG_LSSPGTKLVADGGRRGTEGA_KWLTDHHRRRAPGGRGGAGYRSTIRRTWTQLPYGNGDSA_SRAIHWYRAVGNHAVQPSNRCVTSRVSDKSCRTAARFARRRDGRLIRLGRRRIR_SLRPHRIDID_GRRV

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding PpsA with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

13 show intermediate predicted evidence for PPIs

24 show weak predicted evidence for PPIs

View all pooled AlphaFold results for PpsA

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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