mmpL4
mL2378
PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL4
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 2846834 – 2849713
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL2378_mmpL4_dna
TCAAATGCGCGAACGACCTGGACACCCACACCAAGCCACCGTTCGTCGCAAGGATGATCCACAGATTTGCGGTACCGATCATCTTGGTATGGTTAGCCATTGCCGTCACCGTTAGTGTCTTTATCCCATCACTAGAAGACGTTGGGCAAGAGCGTTCAGTGTCGCTAAGCCCTAAGGACGCACCGTCGTACATTGCGATGCAGAAGATGGGTCAGGTCTTCAACGAAGGAAACTCCGACAGTGTAATAATGATCGTCCTGGAAGGCGATAAGCCGCTCGGTGACGATGCTCACAGATTTTACGATGGCCTGATTCGCAAGTTGCGGGCAGACAAGCACGTGCAAAGCGTTCAAGACTTTTGGGGGGATCCTCTTACCGCGCCCGGCGCCCAAAGCAATGACGGTAAGGCCGCCTATGTCCAATTGAGTCTAGCGGGTAACCAAGGTGAGTTGCTGGCTCAAGAATCCATCGATGCGGTCCGCAAAATCGTCGTGCAGACGCCTGCGCCTCCCGGAATAACGGCTTGGGTCACTGGAGCGTCAGCCTTGATCGCGGACATGCATCATAGTGGCGACAAATCCATGATCCGGATCACCGCAACGAGTGTGATCGTGATTTTGGTGACGTTGCTGCTCGTCTATCGATCGTTCATCACCGTGATTCTGCTGCTTTTCACGGTCGGGATCGAATCGGCGGTGGCGCGGGGAGTCGTCGCGTTGCTCGGACATACCGGGCTCATCGGTCTGTCCACCTTCGCGGTGAATCTGCTCACATCCTTGGCCATCGCGGCGGGCACTGACTACGGGATATTTATCACTGGGCGCTACCAGGAGGCCCGCCAGGCCAACGAAAACAAAGAAGCGGCCTTCTACACTATGTACCGGGGAACTTTCCACGTCATCTTAGGCTCTGGGTTGACAATCTCCGGGGCGACGTTTTGCCTCAGCTTCGCCCGGATGCCCTATTTCCAAACTTTGGGTGTCCCGTGCGCGGTGGGGATGCTCATCGCCGTGGCGGTCGCACTCACCCTCGGACCGGCGGTGTTGACGGTCGGCAGCCGTTTCGGTCTGTTTGAACCCAAAAGGCTGATCAAGGTCCGTGGCTGGCGACGGATCGGCACCGTGGTGGTCCGCTGGCCGCTGCCCATTCTCATCACCACCTGCGCTATCGCCATGGTCGGTCTGCTGGCTCTGCCCGGATACCGGACTAACTACAAGGACCGGGCGTATCTTCCTGCGTCCATCCCCGCCAACCAAGGATTTGCCGCCGCGGATCGCCATTTCCCACAGGCCCGGATGAAGCCCGAAATTTTAATGATCGAGTCGGATCATGATATGCGAAATCCGGCCGACTTTTTGATCCTGGACAAGCTGGCCAGGGGAATCTTTCGTGTTCCAGGAATTTCCCGGGTCCAGGCGATAACCAGACCCGACGGAACGGCAATGGATCATACTTCGATACCATTTCAGATAAGCATGCAAAATGCCGGACAAGTACAAACCATGAAGTATCAGAAGGACCGGATGAATGACCTTCTAAGACAGGCAGAAAATATGGCCGAAACGATTGCTTCGATGAGGCGTATGCATCAATTAATGGCGTTGCTCACAGAAAATACTCACCACATTTTAAACGACACTGTAGAAATGCAAAAAACTACCAGCAAGTTGCGTGATGAAATAGCTAATTTTGATGATTTCTGGCGACCGATTCGTAGCTATTTCTACTGGGAAAGACATTGTTTTAACATTCCGATATGCTGGTCATTTCGATCAATATTCGATGCGCTGGACGGCGTGGACCAGATCGACGAGAGACTGAACTCGATCGTTGGTGACATCAAAAACATGGATCTGCTGATGCCGCAGATGTTGGAGCAATTCCCGCCGATGATCGAAAGCATGGAGAGCATGCGCACCATCATGCTGACCATGCACAGCACAATGTCTGGGATCTTTGATCAGATGAACGAGCTGAGCGACAACGCCAATACGATGGGGAAGGCATTCGACACTGCCAAAAATGACGACTCATTTTACCTTCCACCCGAGGTCTTCAAGAACACCGATTTCAAGCGCGCGATGAAATCATTCCTGTCATCGGATGGACACGCGGCTCGCTTCATTATTTTACATCGGGGGGATCCCGCCAGCGTCGCGGGTATCGCGAGTATCAACGCGATACGCACGGCAGCCGAGGAGGCTCTCAAGGGCACCCCATTGGAGGACACCAAGATCTACCTGGCCGGTACGGCGGCCGTCTTCAAGGACATCGACGAGGGCGCTAACTGGGATCTCGTGATCGCGGGGATTTCATCGCTTTGCCTGATTTTCATCATCATGCTGATCATTACTCGAGCCTTTGTAGCCGCCGCTGTTATCGTGGGTACGGTCGCGCTTTCACTAGGCGCCTCCTTTGGACTGTCCGTATTGCTCTGGCAGCATATTCTCGGTATCGAATTGCACTATCTGGTGCTTGCGATGTCGGTTATCGTGCTGTTGGCGGTAGGATCTGACTACAACCTGCTGCTGGTGTCGCGGTTCAAACAGGAAATCCAGGCCGGATTGAAGACCGGCATCATCCGTTCGATGGGCGGCACCGGCAAAGTCGTGACGAACGCTGGGCTGGTGTTCGCGTTCACGATGGCATCCATGGTCGTCAGCGACCTGCGGGTGATCGGGCAGGTGGGTACCACCATCGGTCTGGGTCTATTGTTCGACACGTTGATCGTGCGCTCGTTCATGATGCCCTCGATCGCTGCCCTGCTGGGACGCTGGTTCTGGTGGCCGCAACAGGGCCGCACTCGACCGTTGTTGACCGTGGCTGCTCCGGTTGGATTACCTCCAGACCGGTCCCTGGTGTACAGCGACTAACTGTTAG

Protein Sequence 

>ML2378_MmpL4_protein
SNARTTWTPTPSHRSSQG_STDLRYRSSWYG_PLPSPLVSLSHH_KTLGKSVQCR_ALRTHRRTLRCRRWVRSSTKETPTV___SSWKAISRSVTMLTDFTMA_FASCGQTSTCKAFKTFGGILLPRPAPKAMTVRPPMSN_V_RVTKVSCWLKNPSMRSAKSSCRRLRLPE_RLGSLERQP_SRTCIIVATNP_SGSPQRV_S_FW_RCCSSIDRSSP_FCCFSRSGSNRRWRGESSRCSDIPGSSVCPPSR_ICSHPWPSRRALTTGYLSLGATRRPARPTKTKKRPSTLCTGELSTSS_ALG_QSPGRRFASASPGCPISKLWVSRARWGCSSPWRSHSPSDRRC_RSAAVSVCLNPKG_SRSVAGDGSAPWWSAGRCPFSSPPALSPWSVCWLCPDTGLTTRTGRIFLRPSPPTKDLPPRIAISHRPG_SPKF__SSRIMICEIRPTF_SWTSWPGESFVFQEFPGSRR_PDPTERQWIILRYHFR_ACKMPDKYKP_SIRRTG_MTF_DRQKIWPKRLLR_GVCIN_WRCSQKILTTF_TTL_KCKKLPASCVMK_LILMISGDRFVAISTGKDIVLTFRYAGHFDQYSMRWTAWTRSTRD_TRSLVTSKTWIC_CRRCWSNSRR_SKAWRACAPSC_PCTAQCLGSLIR_TS_ATTPIRWGRHSTLPKMTTHFTFHPRSSRTPISSAR_NHSCHRMDTRLASLFYIGGIPPASRVSRVSTRYARQPRRLSRAPHWRTPRSTWPVRRPSSRTSTRALTGIS_SRGFHRFA_FSSSC_SLLEPL_PPLLSWVRSRFH_APPLDCPYCSGSIFSVSNCTIWCLRCRLSCCWR_DLTTTCCWCRGSNRKSRPD_RPASSVRWAAPAKS_RTLGWCSRSRWHPWSSATCG_SGRWVPPSVWVYCSTR_SCARS_CPRSLPCWDAGSGGRNRAALDRC_PWLLRLDYLQTGPWCTATNC

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding MmpL4 with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

3 proteins show strong predicted evidence for PPIs

14 show intermediate predicted evidence for PPIs

103 show weak predicted evidence for PPIs

View all pooled AlphaFold results for MmpL4

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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