hemL
mL2414c
PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2%2C1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 2884711 – 2886051
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL2414c_hemL_dna
GGTAATCGTGGGCAGCACTGACCAGGCAACCGCACCGGCCGGCCCAGCCGTAAGCATTTCGGCGAAGCTGTTTGAGGATGCCTGCGCCGTCATTCCCGGTGGGGTGAACTCCCCGGTACGCGCCTTCTCGGCGGTCGGTGGCACCCCGCTCTTCATCACCGAAGCGCGCGGTTGCTGGCTAACCGACGCCGACGGCCGCCGCTATGTCGATCTGGTCTGCTCGTGGGGGCCGATGATCCTCGGTCATGCGCATCCCGCCGTGGTTGACGCTGTCGCTACCGTTGCTGCCTCCGGGCTGTCGTTCGGGGCACCGACTCCGGCGGAGACGCAGCTGGCCGCCGAGATCATCGGGCGGATGGCGCCCGTCGAGCGAATACGGCTGGTGAACTCTGGCACTGAAGCCACCATGAGCGCGGTCCGGTTGGCCCGTGGATTCACCGGACGGACCAAGATCATAAAGTTCTCTGGCTGCTATCACGGCCATGTGGACGCGCTATTAGCCGACGCGGGCTCTGGGGTGGCGACGCTGAGCCTACCGTCCTCGCCGGGAGTGACTGGAGCCGCCGCAGCTGACACAATTGTGTTGCCCTACAATGACATCGAGGCCGTTCGGCAGACGTTTGCCCGGTTGGGGGACCAGATCGCCGCGGTGATTACCGAAGCGAGTCCCGGCAATATGGGAGTTGTCCCACCCGCGCCCGGCTACAACGCGGCGCTGCGCGCGATCACCGCAGAGCATGGTGCGCTACTGATCATCGACGAGGTGATGACCGGTTTCCGGGTCAGCCGAAGTGGTTGGTACGGGCTCGATCCGGTCGCCGCTGACTTGTTCATCTTCGGGAAGGTGATGAGCGGCGGAATGCCGGCCGCTGCGTTCGGCGGGCGAGCTGAGGTGATGGAGAGGCTGGCGCCGTTGGGGCCGGTGTATCAGGCGGGGACTCTGTCGGGTAACCCGGTGGCGATGGCCGCCGGGCTGGCAACGCTACGGGCTGCCGCCGACGCAGTTTATGCTACACTGGACCGCAACGCCGACCGGTTGGTTGCAATGCTGTCTGAGGCGCTTACGGATGCCGGTGTTCCACATCAGATTCCGCGTGCCGGCAATATGTTCAGCGTGTTCTTTTCCGAAGCGCCTGTGACCGACTTTGCGTCCGCTTGCAACAGCCAGGTCTGGCGTTATCCGGCGTTTTTTCATGCCTTGCTGGACGCGGGCGTCTACCCGCCGTGCAGTACGTTCGAGGCGTGGTTTGTCTCGGCCGCTCTCGACGACGCCGCGTTCGGTCGCATCGTTGATGCTCTGCCCGGTGCGGCCGCTGCCGCAGTCGCCGCCCGGCATCGGGA

Protein Sequence 

>ML2414c_HemL_protein
GNRGQH_PGNRTGRPSRKHFGEAV_GCLRRHSRWGELPGTRLLGGRWHPALHHRSARLLANRRRRPPLCRSGLLVGADDPRSCASRRG_RCRYRCCLRAVVRGTDSGGDAAGRRDHRADGARRANTAGELWH_SHHERGPVGPWIHRTDQDHKVLWLLSRPCGRAISRRGLWGGDAEPTVLAGSDWSRRS_HNCVALQ_HRGRSADVCPVGGPDRRGDYRSESRQYGSCPTRARLQRGAARDHRRAWCATDHRRGDDRFPGQPKWLVRARSGRR_LVHLREGDERRNAGRCVRRAS_GDGEAGAVGAGVSGGDSVG_PGGDGRRAGNATGCRRRSLCYTGPQRRPVGCNAV_GAYGCRCSTSDSACRQYVQRVLFRSACDRLCVRLQQPGLALSGVFSCLAGRGRLPAVQYVRGVVCLGRSRRRRVRSHR_CSARCGRCRSRRPASG

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding HemL with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

0 show intermediate predicted evidence for PPIs

4 show weak predicted evidence for PPIs

View all pooled AlphaFold results for HemL

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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