hemD
mL2420c
PROBABLE UROPORPHYRIN-III C-METHYLTRANSFERASE HEMD (UROPORPHYRINOGEN III METHYLASE) (UROGEN III METHYLASE) (SUMT) (UROGEN III METHYLASE) (UROM)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 2894843 – 2896534
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL2420c_hemD_dna
GAACGGGAGTGGTGGGAGCGACAATGACGACGCGAGGGCGTAAGCTTAGACCAGGTCGCATCACATTTGTGGGCGCCGGTCCAGGAGCCCCAGGGTTACTAACTGCTCAGGCTGTAGCGGTGCTAGCAAACGCCGCCCTTGTTTTTATCGACCCCGATGTACCTGAACCGGTGCTGGCGCTGATTGGCAAGGACTTGCCACCGGTCTCTGGTCCGGCGCCTGCCGGTCCGGCTGCCGTGACCGCCGGCAGGGCTGCTGACGGTACCCTCGAGGGGGATCACTACCAAGCCGCACCGATGGTCATGTCCGGAGGCGCCGACATCCGCCCTGCGTTGGGTGACCCTACTGAGGTCGCCAAAACGCTGACCGCCGAGGCTCGTTCCGGTGTTGATGTGGTGCGCTTAGTGGCGGGTGATCCGTTGACGGTGGACGCGGTCATAGCCGAGGTGAACGCTGTGGCACGCACCAATCTACAAATCGAGATCGTGCCCGGCTTGGTCACCAGCAGCGTCGTACCAACCTATGCCGGGCTACCCTTGGGTTCGTCGCACACGGTGGCTGATGTACGTGGCGACGTGGACTGGGAAGCGCTAGCCGCGGCTCCTGGGCCGTTGATTCTGCAAGCCACCGCATCACATCTTGCCGACGCGGCGCACATCTTGATCGACCACGGGCTGGACGACGCCACACCCTGCGTGGTGACCGCTCAGGGCACGACCTGCCAGCAACGTTCTGTCGAAACCACATTGGAGGGATTGGCTGACTCGGCTGTCCTGGTCGGCACCGATACCGCAGGCCCGCTGACCGGGCCGCTGGTGGTGACCATAGGCAAGACGGTGACCAGTCGAGCTAGACTGAACTGGTGGGAAAGCCGTGCACTCTACGGCTGGACCGTGTTGGTACCGCGTACCAAGGACCAGGCCGGCGAGATGAGCGAGCGGCTGACGTCGTACGGTGCGTTGCCGGTTGAGGTGCCGACCATCGCTGTCGAGCCGCCGCGCAGTCCCGCTCAGATGGAACGTGCTGTCAAGGGGCTGGTCGACGGTCGTTTCCAATGGGTGGTGTTCACCTCCACCAACGCGGTGCGCGCGGTGTGGGAGAAGTTTGGCGAGTTCGGTCTGGATGCCCGCGCCTTCTCCGGGGTGAAGATCGCCTGTGTCGGAGAAGCGACTGCCGACAGGGTCCGTGCATTCGGGATCAGCCCGGAGCTGGTGCCGGCTGGGGAACAGTCTTCCCTCGGTCTACTGGACGAATTCCCGCCTTATGACAGCGTTTTCGACCCGGTGAACCGTGTTTTGCTGCCGCGCGCTGACATTGCCACCGAAACCCTGGCTGAGGGACTGCGCGGGTGTGGCTGGGAGATCGAGGACGTCACCGCTTATCGGACGGTGCGGGCGGCACCGCCGCCGGCGGCCACCCGGGAAATGATCAAGACGGGTGGCTTCGATGCAGTGTGCTTCACCTCCAGCTCCACGGTGCGTAACTTGGTTGGTATTGCCGGCAAACCGCACGCGCGGACGGTCATTGCCTGCATCGGACCCAAGACTGCTGAGACCGCTTCCGAATTTGGTTTGCGGGTGGATGTCCAGCCCGAAACCGCCGCGGTTGGACCGTTAGTTGATGCGTTGGCCGAACATGTCGCTCGACTGCGCGCCGAAGGCGCGCTGCCTCCACCGCGCAAGAAGAGCCGCA

Protein Sequence 

>ML2420c_HemD_protein
EREWWERQ_RREGVSLDQVASHLWAPVQEPQGY_LLRL_RC_QTPPLFLSTPMYLNRCWR_LARTCHRSLVRRLPVRLP_PPAGLLTVPSRGITTKPHRWSCPEAPTSALRWVTLLRSPKR_PPRLVPVLMWCA_WRVIR_RWTRS_PR_TLWHAPIYKSRSCPAWSPAASYQPMPGYPWVRRTRWLMYVATWTGKR_PRLLGR_FCKPPHHILPTRRTS_STTGWTTPHPAW_PLRARPASNVLSKPHWRDWLTRLSWSAPIPQAR_PGRWW_P_ARR_PVELD_TGGKAVHSTAGPCWYRVPRTRPAR_ASG_RRTVRCRLRCRPSLSSRRAVPLRWNVLSRGWSTVVSNGWCSPPPTRCARCGRSLASSVWMPAPSPG_RSPVSEKRLPTGSVHSGSARSWCRLGNSLPSVYWTNSRLMTAFSTR_TVFCCRALTLPPKPWLRDCAGVAGRSRTSPLIGRCGRHRRRRPPGK_SRRVASMQCASPPAPRCVTWLVLPANRTRGRSLPASDPRLLRPLPNLVCGWMSSPKPPRLDR_LMRWPNMSLDCAPKARCLHRARRAA

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding HemD with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

1 shows intermediate predicted evidence for PPIs

8 show weak predicted evidence for PPIs

View all pooled AlphaFold results for HemD

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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