hemC
mL2421c
PROBABLE PORPHOBILINOGEN DEAMINASE HEMC (PBG) (HYDROXYMETHYLBILANE SYNTHASE) (HMBS) (PRE-UROPORPHYRINOGEN SYNTHASE)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 2896541 – 2897497
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL2421c_hemC_dna
GTAGTTGATTGGCCCACGTGATCCGGATAGGCACTCGGGGTAGCTTGTTAGCCACCACTCAGGCTGCGCTCGTTAGAGACGCTCTCATAGCCAACGGGCATCCTGCGGAGTTGGTGATCGTCAATACCGCGGGCGATCAGTCGTCTGCGTCTATCGACAGTCTAGGTGTGGGCGTCTTCACCACCGCATTGCGTGCGGCTATCGAAGAGGGCTGCGTCGATGCTGCGGTGCACTCGTACAAGGATTTGCCAACTGCTGACGATCCGCGGTTCACGGTAGCGGCGATTCCTCCACGAAATGACCCCCGCGACGCAGTGGTAACTCGCGATGAGCTGGTTCTTGCTGAATTGCCGGCTGGATCGCTGGTAGGCACGTCATCGCCGCGGCGGGCAGCTCAGCTTAGGGCATTGGGTCTCGGTTTGGAAATTCGCCCCCTACGAGGCAACCTAGATACCAGGTTGAACAGGGTAAGCAGTGGCGATCTTGACGCCATCGTGGTGGCCCGGGCCGGGTTGGCCCGGCTGGGCCGCCTCGATGAAGTCACCGAGACGTTAGATCCGGTGCAGATGGTGCCAGCACCGGCTCAAGGCGCGATCGCGGTCGAATGCCGCGCTGGTGACAGTCGGTTGGTGGCGGTGCTGGCGGCGTTGGACGATGCCGACACACGTGCGGCGGTCACCGCGGAGCGAGTCCTGCTCGCCGAACTGGAGGCCGGCTGCTCCGCACCGGTGGGCGCGATCGCTCAAGTGGTCGAGTCCATCGATGGGGAAGGCCGCGTCTTCGAAGAGTTGTCGTTGCGCGGCTGCGTGGCGGCGTTGGACGGATCCGACGTGATCCGCGCGTCCGGCATCAGCACGTCCGGTCGGGCGAGCGAGCTTGGGCTAGCAGTTGCCGTGGAGCTGTTTGAGCTGGGTGCCCGGGAGCTGATGTGGGGAGCGCGGTCAGACCGGGCGCGAG

Protein Sequence 

>ML2421c_HemC_protein
VVDWPT_SG_ALGVAC_PPLRLRSLETLS_PTGILRSW_SSIPRAISRLRLSTV_VWASSPPHCVRLSKRAASMLRCTRTRICQLLTIRGSR_RRFLHEMTPATQW_LAMSWFLLNCRLDRW_ARHRRGGQLSLGHWVSVWKFAPYEAT_IPG_TG_AVAILTPSWWPGPGWPGWAASMKSPRR_IRCRWCQHRLKARSRSNAALVTVGWWRCWRRWTMPTHVRRSPRSESCSPNWRPAAPHRWARSLKWSSPSMGKAASSKSCRCAAAWRRWTDPT_SARPASARPVGRASLG_QLPWSCLSWVPGS_CGERGQTGRE

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding HemC with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

1 protein shows strong predicted evidence for PPIs

1 shows intermediate predicted evidence for PPIs

53 show weak predicted evidence for PPIs

View all pooled AlphaFold results for HemC

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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