clpB
mL2490c
PROBABLE ENDOPEPTIDASE ATP BINDING PROTEIN (CHAIN B) CLPB (CLPB PROTEIN) (HEAT SHOCK PROTEIN F84.1)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 2963228 – 2965774
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL2490c_clpB_dna
AGATCGTCGTGGACTCTTTCAACCCGACCACCAAAATGCAGGTGGCTCTAACTTCAGCGCTGCAGGCAGCGTCGTCCGCAGGTAATCCCGAGATCAGACCTGTGCATTTGCTATTGGCGATGCTCATGCAAAACGACGGAATCGCCGCACCGTTGTTGGAGACTGTCGGTGTGGAGCCCGACATCGTTCGCAATGAGGCACAGCGGCTCCTGGAGCGATTACCCCAGGCCAGCGGCTGCAGCTCGCAGCCGCAGTTGTCGCGAGAGTCGTTGGCTGCCATCACCACCGCTCAGCAGCTCGCTACCGAGATGGACGACGAGTACGTGTCGACCGAGCACCTGATGCTAGGGTTAGCCATGGGCGACTCCGATGTCGCGAAGCTGCTTACCGGGCACGGTGCCTCGCCGCAGGTGTTACGGGAGGCGTTCGTCAAGATACGTGGCAGTGCCCGAGTCACTAGCTCCGATCCCGAGTTCACCTATCAAGCGTTGGAGAAGTACTCCACAGATCTGACCGCCCAGTCCGGCGAAGGCAAACTTGACCCAGTTATCGGGCGCGACAACGAGATCCGTCGTGTTGTGCAGGTGCTGTCCCGTCGCACCAAGAACAACCCGGTGCTTATCGGCGAGCCTGGTGTCGGCAAGACCGCGATCGTGGAGGGCTTGGCTCAGCGCATCGTTGCCGGCGATGTGCCGGAGAGCCTGCGTGACAAGACCTTGGTAGCGCTGGATCTCGGGTCAATGGTGGCTGGCGCCAAGTATCGCGGCGAGTTCGAACAACGACTCAAGGTCGTGCTCGACGACATCAAATTCTCTGCTGGACAGATCATCACGTTTATCGATGAGTTGCACACTATCGTCGGAGCCGGTGCGACTGGTGAGTCGGCGATGGATGCTGGCAACATGATCAAGCCGATGCTGGCCCGTGGCGAATTGCGCCTGGTCGGCGCCACCACGCTTGACGAGTACCGCAGGTACATCGAGAAGGATGCAGCGCTGGAGCGGCGCTTCCAGCAGATCTTCGTCGGCGAGCCGTCGGTGGAGGACACTGTTGGCATCCTGCGTGGGCTGAAGGACCGTTACGAGGTGCACCACGGTGTGCGCATCACCGACTCTGCTCTGGTAGCTGCGGCAGCCCTCTCCGACCGTTATATCACCGCCCGGTTCCTGCCGGACAAGGCCATCGACCTGGTCGACGAAGCGGCTAGCCGGTTACGCATGGAGATCGACTCGCGGCCTGTCGAGATCGACGAGGTTGAGCGGCTGGTGCGTCGCTTCGAGATCGAAGAGATGGCTCTTGTGAACGAAGAAGACGAAGCATCCAAGGAGCGTTTGGAGACGTTGCGTGCGGAACTGGCTGACCAGAAGGAGCGGCTCGCCGAGCTAACCGCGAGGTGGCAGAATGAAAAGAACGCGATAGATGTCGTCCGAGAACTTAAGGAACAGTTGGAGACGTTGCGCGGGGAATCCGAGCGTGCTGAGCGTGACGGTGACCTGGCCAAGGCCGCTGAGCTGCGGTATGGGCGCATCCCCGAGGTTGAAAAGAAGCTGGAAGCGGCGGTGCCGACGGCCCAGGCCCGCGAGGACGTGATGCTCAAGGAAGAGGTCGGTCCTGACGATATCGCCAACGTGGTGTCAGCGTGGACCGGCATACCGGCTGGCCGGTTGTTGGAGGGCGAGACCGCCAAGCTGCTGCGTATGGAGGACGAACTGGGCAAGCGTGTGGTCGGGCAGAAGAAGGCAGTGCACGCGGTCTCTGACGCGGTGCGACGCTCGCGGGCCGGGGTTGCCGACCCTAACCGGCCGACCGGCTCGTTTTTGTTTCTTGGCCCGACCGGTGTCGGCAAGACCGAGCTGGCCAAAGCACTGGCTGATTTCCTGTTTGACGACCAGCGCGCGATGGTCCGTGTGGACATGAGCGAGTACGGTGAGAAGCATTCGGTGGCCCGTCTGGTGGGTGCACCGCCCGGCTACATTGGCCACGATCAGGGTGGTCAGCTGACCGAGGCGGTGCGCCGACGGCCTTACACGGTGGTGCTTTTCGACGAGGTCGAAAAGGCCCACTCGGATGTCTTCGATGTGCTACTGCAGGTGCTCGACGAAGGCCGTTTGACTGACGGGCAGGGCCGCACGGTCGACTTTCGCAACACGATCCCCATCTTGACCTCCAACCTGGGGTCGGGCGGCAGCGAGGAGCAGGTAATGGCAGCGGTGCGCTCGGTGTTCAAGCCGGAGTTCATCAACCGCCTCGACGACGTACTGATCTTCGACGGGCTCAACCCCGAAGAGTTGGTGCGGATTGTCGACATTCAGCTTGAGCAGCTTGGCAAGCGGCTCGCGCAGCGGCGGCTTCAACTGGAGGTTTCGTTGCCGGCTAAGCGCTGGTTGGCACAGCACGGCTTCGATCCTGTATACGGCGCCCGGCCATTGCGTCGACTGGTACAGCAAGCGATCGGCGATCAATTGGCTAAAATGCTGCTGGCCGGCGAGGTGCATGACGGGGACACCCTTCCGGTCAACGTCAGACCCGACGGGGAGGCGTTGATCC

Protein Sequence 

>ML2490c_ClpB_protein
RSSWTLSTRPPKCRWL_LQRCRQRRPQVIPRSDLCICYWRCSCKTTESPHRCWRLSVWSPTSFAMRHSGSWSDYPRPAAAARSRSCRESRWLPSPPLSSSLPRWTTSTCRPST_C_G_PWATPMSRSCLPGTVPRRRCYGRRSSRYVAVPESLAPIPSSPIKRWRSTPQI_PPSPAKANLTQLSGATTRSVVLCRCCPVAPRTTRCLSASLVSARPRSWRAWLSASLPAMCRRACVTRPW_RWISGQWWLAPSIAASSNNDSRSCSTTSNSLLDRSSRLSMSCTLSSEPVRLVSRRWMLAT_SSRCWPVANCAWSAPPRLTSTAGTSRRMQRWSGASSRSSSASRRWRTLLASCVG_RTVTRCTTVCASPTLLW_LRQPSPTVISPPGSCRTRPSTWSTKRLAGYAWRSTRGLSRSTRLSGWCVASRSKRWLL_TKKTKHPRSVWRRCVRNWLTRRSGSPS_PRGGRMKRTR_MSSENLRNSWRRCAGNPSVLSVTVTWPRPLSCGMGASPRLKRSWKRRCRRPRPART_CSRKRSVLTISPTWCQRGPAYRLAGCWRARPPSCCVWRTNWASVWSGRRRQCTRSLTRCDARGPGLPTLTGRPARFCFLARPVSARPSWPKHWLISCLTTSARWSVWT_ASTVRSIRWPVWWVHRPATLATIRVVS_PRRCADGLTRWCFSTRSKRPTRMSSMCYCRCSTKAV_LTGRAARSTFATRSPS_PPTWGRAAARSR_WQRCARCSSRSSSTASTTY_SSTGSTPKSWCGLSTFSLSSLASGSRSGGFNWRFRCRLSAGWHSTASILYTAPGHCVDWYSKRSAINWLKCCWPARCMTGTPFRSTSDPTGRR_S

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding ClpB with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

1 shows intermediate predicted evidence for PPIs

22 show weak predicted evidence for PPIs

View all pooled AlphaFold results for ClpB

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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