dnaK
mL2496c
PROBABLE CHAPERONE PROTEIN DNAK (HEAT SHOCK PROTEIN 70) (HEAT SHOCK 70 KDA PROTEIN) (HSP70)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 2971574 – 2973436
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL2496c_dnaK_dna
GAATCACCATGGCTCGTGCGGTCGGCATCGACCTCGGGACCACCAACTCCGTCGTCTCCGTTCTGGAGGGTGGCGACCCCGTCGTCGTTGCCAACTCCGAGGGGTCGAGGACCACTCCGTCAACTGTCGCGTTCGCGCGTAACGGCGAGGTTCTCGTCGGCCAACCCGCCAAAAACCAGGCGGTTACTAACGTCGACCGCACCATCCGGTCTGTCAAACGGCACATGGGCAGTGACTGGTCCATCGAAATCGACGGCAAAAAATACACCGCGCAGGAGATCAGCGCCCGCGTTCTGATGAAGCTGAAGAGGGACGCTGAGGCTTACCTCGGTGAGGACATCACCGATGCAGTCATCACCACACCAGCCTACTTTAACGACGCCCAGCGTCAGGCTACCAAGGAAGCCGGCCAGATCGCCGGTTTAAACGTACTGCGTATTGTCAACGAGCCGACCGCCGCCGCTCTGGCCTACGGTCTAGACAAGGGTGAGAGAGAACAAACCATCCTGGTGTTCGATCTGGGTGGCGGCACCTTCGATGTTTCGTTGCTGGAAATCGGCGAGGGCGTGGTCGAAGTGCGTGCCACCAGCGGTGACAATCACCTCGGTGGCGACGATTGGGACGACCGTATTGTCAACTGGCTCGTCGACAAGTTCAAGGGCACTAGCGGTATCGATCTGACCAAGGACAAGATGGCTATGCAGCGGCTACGTGAGGCTGCCGAGAAGGCCAAGATCGAGCTCAGCTCGAGCCAAAGCACCTCGGTTAACTTGCCCTACATTACCGTCGATTCAGACAAGAACCCGCTATTCCTTGACGAGCAGCTTATTCGCGCCGAATTCCAACGCATCACCCAGGATTTGCTGGACCGCACCCGTCAGCCGTTCCAGTCGGTGGTCAAGGACGCCGGTATTTCGGTTTCTGAGATCGATCACGTCGTGCTGGTGGGCGGTTCGACCCGGATGCCTGCGGTGACCGATCTTGTCAAGGAACTCACTGGTGGCAAGGAGCCCAATAAGGGTGTCAACCCCGATGAGGTCGTTGCTGTTGGTGCTGCGTTGCAGGCCGGTGTCCTCAAGGGTGAGGTGAAAGACGTTCTTTTGCTTGATGTTACACCACTGAGCTTGGGTATCGAGACCAAGGGTGGCGTGATGACCAAGCTCATCGAGCGCAATACCACGATCCCCACCAAGCGCTCAGAGACCTTCACTACTGCCGACGACAATCAGCCGTCGGTGCAGATCCAAGTCTACCAGGGTGAGCGCGAGATAGCTTCGCACAATAAGCTTCTCGGCTCTTTCGAGCTGACCGGTATTCCACCGGCTCCGCGCGGTGTCCCGCAGATCGAGGTCACTTTCGACATCGACGCCAACGGCATAGTTCACGTCACTGCCAAGGACAAGGGCACTGGCAAGGAGAATACGATCAAAATCCAGGAAGGCTCCGGGCTGTCCAAGGAAGAGATCGATCGGATGGTCAAGGATGCTGAGGCGCACGCTGAGGAGGACCGCAAGCGTCGCGAGGAGGCCGACGTCCGCAACCAGGCTGAGACGCTCGTGTACCAGACGGAGAAATTCGTCAAGGAACAACGGGAAACCGAGAATGGTTCGAGGGTGCCTGAGGATACCCTCAACAAGGTGGAAGCCGCTGTGGCAGAAGCTAAGACGGCGCTTGGCGGTACCGACATTTCCGCGATAAAGTCGGCAATGGAGAAGCTGGGTCAGGACTCCCAGGCACTGGGGCAGGCGATCTATGAGGCCACCCAGGCTGCGTCGAAGGTGGGCGGCGAGGCTTCCGCGCCTGGTGGCTCGAACTCTACTGACGATGTGGTTGACGCGGAGGTGGTCGACGACGAACGGGAGT

Protein Sequence 

>ML2496c_DnaK_protein
ESPWLVRSASTSGPPTPSSPFWRVATPSSLPTPRGRGPLRQLSRSRVTARFSSANPPKTRRLLTSTAPSGLSNGTWAVTGPSKSTAKNTPRRRSAPAF__S_RGTLRLTSVRTSPMQSSPHQPTLTTPSVRLPRKPARSPV_TYCVLSTSRPPPLWPTV_TRVRENKPSWCSIWVAAPSMFRCWKSARAWSKCVPPAVTITSVATIGTTVLSTGSSTSSRALAVSI_PRTRWLCSGYVRLPRRPRSSSARAKAPRLTCPTLPSIQTRTRYSLTSSLFAPNSNASPRICWTAPVSRSSRWSRTPVFRFLRSITSCWWAVRPGCLR_PILSRNSLVARSPIRVSTPMRSLLLVLRCRPVSSRVR_KTFFCLMLHH_AWVSRPRVA__PSSSSAIPRSPPSAQRPSLLPTTISRRCRSKSTRVSAR_LRTISFSALSS_PVFHRLRAVSRRSRSLSTSTPTA_FTSLPRTRALARRIRSKSRKAPGCPRKRSIGWSRMLRRTLRRTASVARRPTSATRLRRSCTRRRNSSRNNGKPRMVRGCLRIPSTRWKPLWQKLRRRLAVPTFPR_SRQWRSWVRTPRHWGRRSMRPPRLRRRWAARLPRLVARTLLTMWLTRRWSTTNGS

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding DnaK with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

1 protein shows strong predicted evidence for PPIs

5 show intermediate predicted evidence for PPIs

42 show weak predicted evidence for PPIs

View all pooled AlphaFold results for DnaK

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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