pckA
mL2624
PROBABLE IRON-REGULATED PHOSPHOENOLPYRUVATE CARBOXYKINASE [GTP] PCKA (PHOSPHOENOLPYRUVATE CARBOXYLASE) (PEPCK)(PEP CARBOXYKINASE)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 3135283 – 3137112
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL2624_pckA_dna
GCGACTATTCCCGGTCTGGATACCGCTCCAACAAACCACCAGAAGTTGCTGTCGTGGCTAGAGGAGGTCGCTGAACTGACACATCCTGCCCAGGTGGTTTTCGCTGACGGTTCCGACGAAGAATGGCAACAGCTCACCGAGCGACTGGTAGCGGCGGGCACCTTCAAGAAGCTGAACGATGAAAAACACCCCAACTCCTACCTGGCGCTGTCCGATCCCTCTGACGTGGCGCGGGTGGAGTCACGGACCTTTATCTGTTCCGAGCGTGAGATCGATGCCGGACCCACCAACAACTGGATGGACCCCGCTGAAATGCGGTCTACCATGACCGAGCTGTACCGCGGTTGCATGCGCGGCCGCACCATGTGGGTGGTGCCCTTCTGCATGGGTCCGCCGGGTGCTGAGGACCCGAAGTTGGGCGTGGAGATCACCGACTCCGAATACGTTGTTGCGTCGATGAAGGTTATGACTCGGATGGGCACATCCGCCCTAGAGAAGATCGGCGACGACGGGTTCTTCGTCAAGGCCCTGCATTCGGTGGGCGCCCCGCTACAGCCGGGTCAACAAGACATGCCGTGGCCGTGCAACGAAACCAAATACATCACCCATTTCCCGGAGACCCGCGAGATCTGGAGCTACGGCTCCGGCTACGGCGGCAACGCACTGTTAGGGAAGAAGTGCTACTCGCTGCGAATCGCCTCGGCGATGGCCCACGACGAGGGCTGGCTTGCCGAGCACATGCTGATCCTTAAGCTCATTTCCCCGGAGAACAAGGCGTACTACTTCGCGGCGGCGTTCCCGTCGGCCTGCGGCAAGACCAACCTCGCCATGCTGCAACCGACAATCCCGGGCTGGCGCGCTGAAACTCTCGGGGACGACATCGCCTGGATGCGATTCGGCAAGGACGGCCGACTGTACGCGGTCAACCCCGAGTTCGGATTCTTCGGCGTCGCACCGGGCACCAACTGGAAGTCCAACCCGAACGCCATGCGCACCATCGCCGCGGGTAACACCGTCTTCACCAATGTCGCGCTCACCGACGACAACGACGTATGGTGGGAGGGCCTGGAAGGAGAGCCTGCGCATCTGATCGACTGGAAGGGCAACGACTGGTACGCTGGGAAGACGGAGACCCCCGCGGCACATTCGAATTCGCGCTACTGCACGCCGATGTCGCAGTGCCCGATCTTGGCGCCGGAATGGGACGATCCGCGGGGTGTGCCGATCTCAGTCATTCTGTTCGGCGCCCGCCGCAAGACTACAGTGCCGTTGGTAACGCAAGCTCGCAACTGGCAGCACGGCGTTTTCATGGGAGCCACCATGGGTAGCGAACAGACCGCCGCAGCCGAAGGCAAGGTCGGTACGGTTCGGCGCGACCCGATGGCCATGTTGCCATTCATGGGCTACCACGTCGGCGACTACTTTCAGCACTGGATCGATCTGGGCAAACACTCCGACGAATCCAATCTACCGAAGGTGTTCTTCGTCAACTGGTTCCGCCGCGGCGAAGGCGGCAAATTCTTATGGCCGGGCTTCGGCGAGAACAGCCGGGTGTTGAAGTGGATCGTTGACCGCATCGAGCACAAGGCAGGCGGACAGGACACCCTGATCGGCATCGTGCCGACCGCCACGGACCTGGACCTGGACGGACTCGACATCAGCAGCGACGACGTTGCCAAGGCTCTCGCGGTCGACCCCGCCGAGTGGCGCAATGAACTGCCGTTGATTGAAGAGTGGTTCGAGTTCGTCGGCGACAAGTTGCCCTCTGGCATGCAGGATGAATTCGAAGCACTCAAGCAGCGGCTGGCAAAGGAGGACTAACAGCCAATC

Protein Sequence 

>ML2624_PckA_protein
ATIPGLDTAPTNHQKLLSWLEEVAELTHPAQVVFADGSDEEWQQLTERLVAAGTFKKLNDEKHPNSYLALSDPSDVARVESRTFICSEREIDAGPTNNWMDPAEMRSTMTELYRGCMRGRTMWVVPFCMGPPGAEDPKLGVEITDSEYVVASMKVMTRMGTSALEKIGDDGFFVKALHSVGAPLQPGQQDMPWPCNETKYITHFPETREIWSYGSGYGGNALLGKKCYSLRIASAMAHDEGWLAEHMLILKLISPENKAYYFAAAFPSACGKTNLAMLQPTIPGWRAETLGDDIAWMRFGKDGRLYAVNPEFGFFGVAPGTNWKSNPNAMRTIAAGNTVFTNVALTDDNDVWWEGLEGEPAHLIDWKGNDWYAGKTETPAAHSNSRYCTPMSQCPILAPEWDDPRGVPISVILFGARRKTTVPLVTQARNWQHGVFMGATMGSEQTAAAEGKVGTVRRDPMAMLPFMGYHVGDYFQHWIDLGKHSDESNLPKVFFVNWFRRGEGGKFLWPGFGENSRVLKWIVDRIEHKAGGQDTLIGIVPTATDLDLDGLDISSDDVAKALAVDPAEWRNELPLIEEWFEFVGDKLPSGMQDEFEALKQRLAKED_QPI

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding PckA with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

0 show intermediate predicted evidence for PPIs

22 show weak predicted evidence for PPIs

View all pooled AlphaFold results for PckA

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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