icd2
mL2672c
PROBABLE ISOCITRATE DEHYDROGENASE [NADP] ICD2 (OXALOSUCCINATE DECARBOXYLASE) (IDH) (NADP+-SPECIFIC ICDH) (IDP)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 3210656 – 3212896
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL2672c_icd2_dna
AGAACAATCATGAGCGCCGAGCAGTGGACCATCATCTACACGCTGACCGACGAGGCGCCGCTGTTAGCGACCTACGCCTTTCTACCGATAGTGCGTGCCTTTACCAAGCCCGCGGGTATTAAGGTCCAGACTAGCGACATCTCCGTGGCAGCACGCATACTGGCCGAGTTTCCCGATTACCTGACCGAAGAGCAACGTGTGCCGAACAACCTTGCCGAACTGGGCCGGTTGACACAGTTACCGGACACCAACATCATCAAGCTGCCGAACATCAGTGCTTCGGTGCCGCAATTGATGGCCGCCATCAAGGAGTTGCAGGCCAAGGGATTCAAGCTTCCAGACTATCCGCAAGATCCGAAGTCCTACCAGGAAATCGACATCCGTAACCGCTACGGTAAATGCCTTGGCAGCGCCGTGAACCCGGTTTTGCGGGAAGGTAACTCCGACCGTCGTGCACCTAAGGCTGTGAAGGAGTACGCACGTAACAACCCGCACAGCATGGGCGAATGGTCGATGGCTTCGCGCACACACGTCGCGACCATGCGGCACGGCGACTTCTATCACGGCGAGAAGTCGATGACTTTAGACCGCGCGCGAGACGTGAAGATGGAGCTGGCAACCAAGAAAGGCAAAATAGTCGTGCTCAAGCCCAAGGTGTCGCTACGGGACGGCGACATCATCGACAGCATGTTCATGAGCAAGAAAGCCCTGTGCGAATTCTACGAGGAGCAGATGGAGGATGCTCGCAAGACCGGCGTGATGTTCTCACTGCACGTTAAAGCGACGATGATGAAAGTGTCTCATCCTATCGTTTTCGGCCACGCGGTGAAAACCTTTTACAAGGAAGCCTTCGCCAAGCACCAGGATCTGTTCGACGAACTGGGCGTAAACGTCAACAACGGGTTAGTCGATCTCTATAGCAAGATTGAGACCCTGACCGCATCGCAGCGCGATGAGATCATCCAAGACCTACATGCGTGCCACGAGCACCGACCCGAGTTGGCTATGGTCGACTCAGCGCGTGGAATTTCGAACTTCTATTCGCCTAGTGATGTCATCGTGGATGCGTCGATGCCAGCGATGATCCGTGCGGGAGGCAAGATGTATGGCGCCGACGGGCGGGCCAAGGACACCAAGGCCGTGAACCCCGAGTCCACCTTTTCCCGCATCTACCAGGAAATCATCAACTTCTGCAAGACCAACGGAGCTTTCGATCCGGCGACTATGGGCACCGTCCCCAACGTTGGCCTCATGGCGCAACAGGCTGAGGAGTACGGCTCGCACGACAAGACATTCGAAATTCCCGAGGACGGCGTCGCCAACATCGTGGACCTCACGACGGGCGAAGTGCTGCTGACCCAGAATGTAGAAACCGGTGATATATGGCGTCTATGCGTCGTTACCGACGCAGCAATTCGCGACTGGGTCAAGCTGGCTGTCAGCCGTATGCGCAACTCCGGCATGCCAGTATTGTTTTGGTTGGACCCTTACCGTCCACACGAGAATGAGTTGATCAAAAAGGTCCGGGCGTACCTGAAGGACCACGACACCAGTGGCCTGGATATCCAGATCATGTCGCAAGTGCGCTCAATGCGTTACACGTGCGAGCGCCTCATCCGCGGGCTAGATACCATCGCCGCCACTGGCAACATCCTGCGGGACTACCTCACCGATCTGTTCCCGATCTTGGAGTTAGGTACCAGCGCCAAAATGTTGTCCATAGTGCCGCTAATGGCCGGTGGCGGGATGTATGAAACCGGGGCGGGTGGATCGGCGCCCAAGCACGTCAAGCAGCTTGTCGAAGAGAATCATCTGCGGTGGGACTCGCTGGGTGAGTTCCTCGCGCTGGCCGTCAGCCTGGAAGACCTGGGCATCAAGACCGGCAATGAGAGGGCCAAAATCTTGGCTAAGACGCTGGATGTCGCAACCGGAAAGTTGCTGGACAACAGGAAGAGTCCGTCACGCAAGGCCGGTGAGCTCGACAACCGTGGAAGCCAGTTCTACCTCGCCATGTACTGGGCTCAAGAGCTTGCCACGCAAACCGATGACCAACATCTGCGGAACTACTTCACCCCACTGGCCGAAACGTTGGCCAAGAACGAATGCACTATCGTCGCCGAGCTCAACGAGGCTCAAGGCAAGGCGGTCGATATCGGTGGTTACTACGCACCGGATGCTGAGCTGGCCAAGGCGGTGATGCGTCCGAGTGCCGTGTTCAATGCTGCGTTGGCGGCTGCTCAA

Protein Sequence 

>ML2672c_Icd2_protein
RTIMSAEQWTIIYTLTDEAPLLATYAFLPIVRAFTKPAGIKVQTSDISVAARILAEFPDYLTEEQRVPNNLAELGRLTQLPDTNIIKLPNISASVPQLMAAIKELQAKGFKLPDYPQDPKSYQEIDIRNRYGKCLGSAVNPVLREGNSDRRAPKAVKEYARNNPHSMGEWSMASRTHVATMRHGDFYHGEKSMTLDRARDVKMELATKKGKIVVLKPKVSLRDGDIIDSMFMSKKALCEFYEEQMEDARKTGVMFSLHVKATMMKVSHPIVFGHAVKTFYKEAFAKHQDLFDELGVNVNNGLVDLYSKIETLTASQRDEIIQDLHACHEHRPELAMVDSARGISNFYSPSDVIVDASMPAMIRAGGKMYGADGRAKDTKAVNPESTFSRIYQEIINFCKTNGAFDPATMGTVPNVGLMAQQAEEYGSHDKTFEIPEDGVANIVDLTTGEVLLTQNVETGDIWRLCVVTDAAIRDWVKLAVSRMRNSGMPVLFWLDPYRPHENELIKKVRAYLKDHDTSGLDIQIMSQVRSMRYTCERLIRGLDTIAATGNILRDYLTDLFPILELGTSAKMLSIVPLMAGGGMYETGAGGSAPKHVKQLVEENHLRWDSLGEFLALAVSLEDLGIKTGNERAKILAKTLDVATGKLLDNRKSPSRKAGELDNRGSQFYLAMYWAQELATQTDDQHLRNYFTPLAETLAKNECTIVAELNEAQGKAVDIGGYYAPDAELAKAVMRPSAVFNAALAAAQ

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding Icd2 with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

2 show intermediate predicted evidence for PPIs

24 show weak predicted evidence for PPIs

View all pooled AlphaFold results for Icd2

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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