ponA1
mL2688c
PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE (PEPTIDOGLYCAN TGASE) + PENICILLIN-SENSITIVE TRANSPEPTIDASE (DD-TRANSPEPTIDASE)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 3236668 – 3238794
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL2688c_ponA1_dna
GGTTGGAGGGTGCCTGGATCGCGGTTAAATCGGACATGGCTCCTACACCTCAACCGGCAGGTGAACTGGCGCTGGGTGCGGTATTCATTGTATCTCGCTGTGGTGGTGTTGTTGTTGTTACCGATCGTCACTTTCACCATGACCTACTTCATGGTGAAAGTTCCCAGGCCAGGTGACATTCGTACTAACCAGGTCTCGACGATCCTGGCCAACAATGGCTTGGAGATCGCCAAAATTGTTCCACCCGAAGGTAACCGGGTCGATGTCAACCTCAGCCAAGTACCGGTGCATGTACGCCAGGCGGTTATTGCTGCAGAGGATCGCAACTTCTATTCAAACCCGGGGTTTGACTTCAGAGCCTCTGTGCGAGCGGTGCAAAACAACCTCTTCGGTAGCGGCGATCTGCAGGGCGGGTCAACTATCACCCAGCAGTATGTGAAGAATGCGTTAGTCGGTTCTGCACAACACGGGTTTGACGGTTTAATGCGCAAGACAAAGGAATTGGTCATCGCCATCAAAATGTCGGACGCATGGTCTAAAGACGATGTGCTACAATCTTATTTGAATATAATATACTTCGGTAGGGGAGCCTACGGAATTTCAGCTGCGGCCAAGGCCTATTTTGACAAACCCGTGGAGCAGCTCACCTGCTCCGAGGGGGCACTGTTGGCGGCGCTAATTCGGCGGCCGTCGGTCCTAGACCCGGCTATCAATCTCAAGGGTGTTACGGCCCGTTGGAACTGGGTGCTGGACGGCATGGTGGACATCAATGCTCTGTCGCCGAATGACCGCTCGGTACAGCTGTTTCCCGCTACCGTGCCGCCTGACCAGGCTCGTGCGCAGAATCAGACCACCGGACCCAATGGACTCATCGAGCGTCAGGTGGTCAAAGAGCTGTTCGAACTATTCAACATCGATCGGCAAACCTTGAACACCCAGGGGCTGCAAGTCATTACCACCATCGATCCGCAGGCTCAACGGATAGTTGAGAAGGCGGTATCGAAATACCTTGACGGGCAGGATCCCGACATGCGTGCTGCCATCGTTTCGATCGATCCACATAACGGTGCGATACGCGCCTACTATGGCGGTGCTGACGCCAACGGTTTTGACTTTGCCCAGGCTGGGCTGCAAACCGGCTCTTCTTTCAAGGTATTTGCGCTCATCGCCGCGCTCGAGCAAGGTATCGGTCTGGGCTATCGGGTCGACAGCTCCCCGCTTACTGTCGATGGTATTAAGATCACCAACAATGGAGACGAGAGTTGTGGAAATTGCAATATCGCTGAGGCGCTCAAGCTCTCGTTGAACACCTCCTATTACCGTCTGATGCTCAAACTTAAGAATGGACCGCAGGCTGTTGCGGACGCCGCGCACCAAGCTGGTATCGTGAGCAGCTTCCCTGGTGTAGCGCACACCCTGTCAGAGGATGGTAAAGGAGGACCGCCCAACAACGGAATCGTTCTGGGCCAGTACGAAACCCGCGTGATCGATATGGCATCGGCATACGCCACGTTGGCTGCGTCCGGCGTCTACCACCGACCGCACTTGGTGCAAAAAGTCGTTAATGCTGAGGGCCGGGTACTTTTCGACGCCAGCACTGCGGACAACAGCGGCGACCAACGCATCGCCAAAGCTGTCGCCGATAACGTTACTGCGGCGATGCAGCCGATTGCCGGTTATTCGCGTGGCCATAACTTAGCTGGCGGGCGGCCGTCGGCAGCCAAAACAGGCACGGTGCAGCTGGGCGATACCACCGCTAACAAGGATGCTTGGATGGTCGGTTACACACCTTCGCTGTCGACGGCGGTGTGGGTTGGTACCGTCAAAGACAATGTGCCGCTGATAACCGCTTCAGGAGAAGCGATTTACGGCTCCGGCCTGCCGTCGGACATCTGGAAGTCGACGATGGATGGCGCTCTGGAGGGTACCCCTAACGAGGGCTTCCCCAAGCCGACTGAGGTAGGTGGCTACGCTGGTGTGCCGACACTGGCACCCCCGCCTCCTTTGAAGAAGGTTATTCAGCCTACTATTGAAGTAGCGCCGGGCATAATCATACCGGTCGGCCCGCCCACGACGGTCACTGTCCCGCCGACGCAGGCATTGCCCGACCTAACAACTTCAACAACG

Protein Sequence 

>ML2688c_PonA1_protein
GWRVPGSRLNRTWLLHLNRQVNWRWVRYSLYLAVVVLLLLPIVTFTMTYFMVKVPRPGDIRTNQVSTILANNGLEIAKIVPPEGNRVDVNLSQVPVHVRQAVIAAEDRNFYSNPGFDFRASVRAVQNNLFGSGDLQGGSTITQQYVKNALVGSAQHGFDGLMRKTKELVIAIKMSDAWSKDDVLQSYLNIIYFGRGAYGISAAAKAYFDKPVEQLTCSEGALLAALIRRPSVLDPAINLKGVTARWNWVLDGMVDINALSPNDRSVQLFPATVPPDQARAQNQTTGPNGLIERQVVKELFELFNIDRQTLNTQGLQVITTIDPQAQRIVEKAVSKYLDGQDPDMRAAIVSIDPHNGAIRAYYGGADANGFDFAQAGLQTGSSFKVFALIAALEQGIGLGYRVDSSPLTVDGIKITNNGDESCGNCNIAEALKLSLNTSYYRLMLKLKNGPQAVADAAHQAGIVSSFPGVAHTLSEDGKGGPPNNGIVLGQYETRVIDMASAYATLAASGVYHRPHLVQKVVNAEGRVLFDASTADNSGDQRIAKAVADNVTAAMQPIAGYSRGHNLAGGRPSAAKTGTVQLGDTTANKDAWMVGYTPSLSTAVWVGTVKDNVPLITASGEAIYGSGLPSDIWKSTMDGALEGTPNEGFPKPTEVGGYAGVPTLAPPPPLKKVIQPTIEVAPGIIIPVGPPTTVTVPPTQALPDLTTSTT

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding PonA1 with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

1 protein shows strong predicted evidence for PPIs

3 show intermediate predicted evidence for PPIs

66 show weak predicted evidence for PPIs

View all pooled AlphaFold results for PonA1

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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