ispE
mL0242
Probable 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase IspE (CMK) (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 317042 – 317977
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL0242_ispE_dna
ATGCCCACCGGGTCGGTCACCGTTCAGGTTCCCGGGAAGATCAATCTCTACCTCGCTGTCGGTGATTGCTGCGATAATGGCTACCACGAGCTGGTGACGGTTTTCCATGCTGTGTCGCTGGTCGACCAGGTTACGGTGCGCAACGCCGACGTGCTGTCGCTCGGACTTGTCGGCGAGGGCGCCAACCACGTGCCCACTGACGAACACAACATTGCCTGGCGGGCGGCCGAGCTAATGGCCGAGCACGTTGGCCGGGCTCCGGACGTTTCGATCATGATTGACAAGTCCATTCCGGTGGCTGGGGGGATGGCGGGCGGCAGCGCCGATGCGGCCGCGGTGTTGGTTGCGATGAACTCGTTGTGGGAACTCAGCCTGCCTCGACGCGATCTGTGCATGCTCGCAGCGAAGCTAGGCAGCGACGTGCCGTTCGCACTACACGGTGGTACCGCGCTGGGGACCGGTCGCGGTGAGGAGCTAGCTACCGTGTTGTCCCGCGCCACTTTCCACTGGGTGTTGGCGTTCGCCGACAGCAGTTTGCTCACTCCGGCGGTGTACACCGAGTTTGACCGGCTCAGGGATGTCGGAAATCCACCACGGCTTGCCGAACCCGGGCCGGTGTTGGCCGCCCTGGTCGCCGCCGATCCCGAACAGTTGGCGCCGTTGCTAGGCAATGAATTGCAAGCGGCCGCGGTCAGCTTGGACCCGGCGCTACGGTGTGCGCTCCGCGCCGGTATGGAAGCGGGTGCGCTCGCGGGCATTGTGTCTGGCTCGGGTCCTACCTGCGCATTCCTGTGTGCCTCGGCGACTTCGGCGATCGATGTCGGTGCGCAGTTGGCAGGGGCGGGTGTCTGTCGCACTGTTCGGGTCGCCACCGGACCAGTACCCGGTGCTCGGGTGGTACATGCGCCCATGAGCCGAGGTCTGAATGACATGTGA

Protein Sequence 

>ML0242_IspE_protein
MPTGSVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEGANHVPTDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSLWELSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLLTPAVYTEFDRLRDVGNPPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPALRCALRAGMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARVVHAPMSRGLNDM

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding IspE with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

3 show intermediate predicted evidence for PPIs

28 show weak predicted evidence for PPIs

View all pooled AlphaFold results for IspE

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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