guaB2
mL0387
Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 480662 – 482251
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL0387_guaB2_dna
TGATCCGTGGCATGTCCAACCTGAAAGAAAGCTCCGATTTCGTTGCCAGTTCGTACGTGCGCCTCGGTGGCCTGATGGACGACCCAGCCGCGACCGGGGGTGACAACCCACACAAGGTGGCCATGCTGGGGCTGACTTTCGACGATGTCCTGCTGTTGCCTGCAGCTTCCGACGTGGTGCCTGCTACTGCAGACATTTCCAGTCAGCTGACCAAGAAGATCAGGCTCAAGGTGCCGTTGGTCAGCTCAGCGATGGATACCGTCACCGAGGCACGGATGGCCATCGCCATGGCTCGGGCGGGCGGCATGGGCGTGCTGCACCGCAATCTGCCTGTTGGCGAACAGGCCGGACAGGTCGAGACGGTGAAGCGGTCTGAGGCTGGCATGGTTACTGATCCGGTCACCTGCCGGCCGGACAACACCTTGGCCCAGGTTGGCGCGTTGTGCGCCCGGTTTCGGATCTCCGGGTTACCAGTGGTCGACGATTCCGGTGCACTGGCTGGCATCATCACCAACCGCGACATGCGGTTCGAGGTCGACCAGTCCAAACAGGTCGCCGAGGTGATGACCAAAACACCGCTGATCACAGCTGCTGAGGGTGTCAGCGCCGACGCGGCATTGGGTTTGTTGCGGCGAAATAAGATCGAAAAGCTGCCCGTTGTCGACGGCCATGGCCGGCTGACCGGGCTGATCACTGTCAAAGACTTCGTTAAAACCGAGCAGCACCCGCTGGCGACCAAGGACAACGATGGTCGGCTGCTGGTGGGTGCGGCCGTCGGTGTCGGCGGAGATGCCTGGGTCCGCGCGATGATGTTAGTCGACGCTGGTGTCGACGTGCTGATCGTCGACACCGCGCACGCGCACAATCGGTTGGTGCTCGACATGGTCGGCAAACTCAAGGTCGAAATTGGCGACCGGGTCCAGGTGATTGGTGGCAATGTCGCTACCAGGTCGGCAGCGGCAGCTTTGGTAGAGGCCGGCGCCGACGCGGTGAAGGTCGGCGTAGGGCCCGGGTCTACTTGCACGACCCGTGTGGTGGCCGGTGTCGGCGCGCCGCAGATTACTGCGATCCTGGAGGCCGTCGCGGCGTGCGGACCGGCGGGCGTTCCTGTCATAGCCGACGGCGGGTTACAGTATTCCGGCGATATCGCCAAGGCGCTGGCCGCCGGCGCGTCGACGACCATGCTGGGTTCTTTGTTGGCTGGCACTGCCGAGGCACCAGGCGAGTTGATCTTCGTCAATGGCAAGCAGTTCAAGAGCTATCGCGGCATGGGGTCGTTGGGCGCCATGCAAGGTAGAGGTGGGGATAAGTCGTATTCCAAGGACCGCTATTTCGCCGACGACGCTTTGTCCGAGGACAAGTTGGTCCCTGAGGGAATCGAGGGCAGGGTGCCGTTCCGTGGTCCGCTGTCGTCAGTGATCCACCAGCTGGTGGGTGGTCTGCGCGCTGCGATGGGTTACACCGGCTCTCCTACCATCGAGGTGTTGCAGCAGGCACAGTTCGTCCGGATAACGCCCGCCGGACTCAAAGAGAGCCACCCGCACGACGTTGCGATGACTGTCGAAGCCCCCAACTATTACCCGCGTTGAC

Protein Sequence 

>ML0387_GuaB2_protein
SVACPT_KKAPISLPVRTCASVA_WTTQPRPGVTTHTRWPCWG_LSTMSCCCLQLPTWCLLLQTFPVS_PRRSGSRCRWSAQRWIPSPRHGWPSPWLGRAAWACCTAICLLANRPDRSRR_SGLRLAWLLIRSPAGRTTPWPRLARCAPGFGSPGYQWSTIPVHWLASSPTATCGSRSTSPNRSPR__PKHR_SQLLRVSAPTRHWVCCGEIRSKSCPLSTAMAG_PG_SLSKTSLKPSSTRWRPRTTMVGCWWVRPSVSAEMPGSAR_C_STLVSTC_SSTPRTRTIGWCSTWSANSRSKLATGSR_LVAMSLPGRQRQLW_RPAPTR_RSA_GPGLLARPVWWPVSARRRLLRSWRPSRRADRRAFLS_PTAGYSIPAISPRRWPPARRRPCWVLCWLALPRHQAS_SSSMASSSRAIAAWGRWAPCKVEVGISRIPRTAISPTTLCPRTSWSLRESRAGCRSVVRCRQ_STSWWVVCALRWVTPALLPSRCCSRHSSSG_RPPDSKRATRTTLR_LSKPPTITRVD

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding GuaB2 with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

0 show intermediate predicted evidence for PPIs

6 show weak predicted evidence for PPIs

View all pooled AlphaFold results for GuaB2

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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