MSMEG4105
ms4105
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M. smegmatis · MC2-155
[AlphaFold] [Orthologs] [Phyre2] [UniProt] [MycoBrowser] [TnSeq DB] [SeqHub]
MC2-155 Coordinates: 4184704 – 4185564
Vulnerability Index (VI):
M. tuberculosis homologs Rv1765A, Rv3475, Rv3380c, Rv3326, Rv3187, [+ 12 remaining orthologs]
M. abscessus homologs MAB2088, MAB2086c
background  +5   0  -5 -10 -15 sgRNA L2FC (+ATc/–ATc) TnSeq Gene Essentiality Predictions (1, 2) Essential Growth Defect Non-Essential Growth Advantage Unknown Operon Legend (3) Operon (1) PMID: 28096490 (2) PMID: 31388080 (3) PMID: 26536359 MSMEG4102 MSMEG4103 MSMEG4104 MSMEG4105 MSMEG4106 MSMEG4107 pntB pntA
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>ms4105_MSMEG4105_dna
AAGGCCCTATCCCCGTGAGTTCCGCGACGACGTCGTGCGCGTGGCCCGCAACCGCGAAGACGGTGTGACGATCGAGCAGATCGCCACCGATTTCGGTGTGCACCCGATGACGCTGCACAAATGGCTTCGCCAGGCCGACATCGACGAGGGCACCAAGCCCGGTAGAACCACCGGCGAGTCCGGTGAGCTGCGTGAGGCCCGGCGTCGGATCAAGCTGCTCGAGCTGGAGAACGAGGTGCTGCGCCGGGCCGCGGCGTATCTGTCACAGGCCAACCTGCCGGGAAAAGGCTCTACCCGCTCGTGAAAGAGCTCGCCGCCGACGGGATCCCCGTCGCGGTGACGTGCCGGGTACTCAAGCTCGCCCGCCAACCGTATTACCGCTGGCTGGCCGCCCCAGTCACCGACGCCGACCTCGTTGAGGCCTACCGCGCCAACGCCCTGTTCGACGCTCACCACGAGGACCCCGAGTTCGGGTACCGCTACCTGGCCGAAGAGGCCCGCGACGCCGGCGAACCGATGGCCGAGCGCACCGCGTGGCGCATCTGCTCGCACAATCGCCTGTGGAGCGTGTTCGGCAAGCGCAAACGCGGCAAGAACGGCAAGCCCGGCCCACCAGTCCACGACGATCTCGTCGAACGTGACTTCACCGCTGAGGCGCCGAATCAGCTGTGGCTGGCCGATATTACCGAACACCGCACCGGCGAGGGCAAGCTCTACCTCTGCGCCATCAAAGACGTGTTCTCCAACCGCATCGTCGGCTACAGCATCGACTCCCGGATGAAGTCCCGACTGGCCACCCGTGCACTGCACAGCGCGGTAGCCCGACGCGGAGATGTCGCCGGGTGCATTCTGCATTCGGATCGTGGATCTCAGTTCAGGTCAAGGAGATTCGTACACGCGCTGCACCATCACGACATGGTCGGCTCCATGGGGCGCGTCGGCGCGGCCGGCGACAACGCAGCCATGGAGAGCTTCTTCAGCCTGCTGCAGAAGAACGTCTTGGACCGCCGCCGTTGGCGCACCCGAGAAGAGCTGCGGATCGCGATCGTCATCTGGATCGAACGGACCTACCATCGCCGCCGGCGCCAGGCCGGCCTCGACCGGTTGACCCCCATCGAGTTCGAAGCCATCATGACCACACCGGCCAGTCAGGCCGCGTGA

Protein Sequence 

>Ms4105_MSMEG4105_protein
VKELAADGIPVAVTCRVLKLARQPYYRWLAAPVTDADLVEAYRANALFDAHHEDPEFGYRYLAEEARDAGEPMAERTAWRICSHNRLWSVFGKRKRGKNGKPGPPVHDDLVERDFTAEAPNQLWLADITEHRTGEGKLYLCAIKDVFSNRIVGYSIDSRMKSRLATRALHSAVARRGDVAGCILHSDRGSQFRSRRFVHALHHHDMVGSMGRVGAAGDNAAMESFFSLLQKNVLDRRRWRTREELRIAIVIWIERTYHRRRRQAGLDRLTPIEFEAIMTTPASQAA

Essentiality:

Call Condition Type Source Notes
Unknown in vitro CRISPRi [Bosch & DeJesus et al. (2021)]
Non Essential in vitro TnSeq [Dragset et al. (2019)]

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