MSMEG2310 (MSMEG2310)

background  +5   0  -5 -10 -15 sgRNA L2FC (+ATc/–ATc) TnSeq Gene Essentiality Predictions (1, 2) Essential Growth Defect Non-Essential Growth Advantage Unknown Operon Legend (3) Operon (1) PMID: 28096490 (2) PMID: 31388080 (3) PMID: 26536359 MSMEG2307 MSMEG2308 MSMEG2309 MSMEG2310 MSMEG2311 MSMEG2312 nrdF2 MSMEG2314
Species: M. smegmatis
Strain: MC2-155
PATRIC Annotation: -
Synonyms:
M. tuberculosis homologs RVBD3049c, RVBD1393c, RVBD0892, RVBD0943c
M. abscessus homologs MAB3920c, MAB2074, MAB2073, MAB4476c, MAB0522c, [+ 13 remaining orthologs]
Gene Start: 2391489
Gene End: 2392988
Vulnerability Index (VI):
VI Lower Bound:
VI Upper Bound:
[AlphaFold] [Orthologs] [Phyre2] [UniProt] [MycoBrowser] [TnSeq DB]

Essentiality:

Call Condition Type Source Notes
Growth Advantage in vitro TnSeq [Akusobi et al. (2022)]
Unknown in vitro CRISPRi [Bosch & DeJesus et al. (2021)]


DNA and Protein Sequence help

DNA Sequence

CACGGACTGGTGGCTGGGCAGTAAAGAGGACAGCCCGCGCCGCATGCCCGCAGACGAGTTCGTCAACCACCTGACCACGATCATGGTCGGCTCCATCAACGGCACCTGCGAGCTGCTGGGCATCCGGATCGACCCGGATCTGCCCCTGCACGAGGGTGTGCAGCGCCGCGAACGCGCCAGTTAGTCACACCAGTCACATCGCGCAACTCTCGGGGTGGTCCGAGCGTTGACAGGTCAGCCACCGCGCCGGACACTGGCAAATATCCGGTACCGGCGTTCCCAGGAAAGGACCTGAAACCATGACGGCTGCCGACCAGCAACCCATCCGGACCCGCGCCCTGGTGATCGGCACCGGGTTCTCCGGGCTGGGCATGGCCATCGAACTGCAGCGCCGTGGCGTCGACTTCCTGATTCTGGAGAAGGCCGACGAGATCGGCGGCACCTGGCGCGACAACACCTACCCGGGATGCGCGTGCGACATCCCGTCGCACATGTACTCGTTCTCGTTCGAGCCCAAGGCCGACTGGAAGCACATGTGGTCCTTCCAGCCCGAGATCCAGGACTACCTGCTGGGCGTGACGGCCAAATACGGACTGCGCCGTCACATCCACTTCAACTCGCACGTCGACCGCGCGCACTGGGACGACGAGGAACTGCGCTGGCATGTGTTCACCAAGACCGGCCAGGAGTACATCGCCCAGTTCCTGGTGTCCGGCGCAGGCGGTCTGCACATCCCGCAGATCCCGGACATCGAAGGCCGGGAGTCGTTCGCGGGCGCGGCTTTTCACTCGGCGCAGTGGGACCACAGCGTCGATTTGCGCGGTAAGCGCGTCGCGGTGATCGGCACCGGCGCCAGTGCCATCCAGATCGTGCCGGAGATCGTCAAGGACGTCGCCGAACTGCACCTGTACCAGCGCACCCCGGCCTGGGTGATGCCACGCGTCAACAACGCGTTCCCGCAATGGCTGCGCAACGTCTTCAGCTACGTCCCCGGCACCCGCGCGCTGCTGCGCGCGGCCATCTACTGGATCCATGAGGGCGTCGGCTTCGCGATGACCAAGGAGCCGCGCCTGCTCAAGATCGGCGAGTGGATGGGCCGCTACAACATCAACCGCAGCATCAAGGACCCCGAGCTGCGGCGTAAGCTCACGCCGAGCTACCGCGCCGGGTGCAAGCGAATCCTCAACTCCGACACCTACTATCGCGGGATCGCCGACCCCAAGACCCAGGTGATCACCGAGGGCATCGCCCGGATGACGCCGACCGGCATCGTCACCAACGACGGCGTCGAGCATCCCGTCGACATCGTCGTCTACGCCACGGGCTTCCACGTGACCGACTCCTACACCTACGTCGACATCAAGGGTGCGGGCGGCGAAGACCTGGTCGACCGCTGGAACCGCGAGGGCATCCAGGCCCACCGCGGCGTCGCCGTCGCCGGCATGCCGAACCTGTTCTTCCTGCTGGGGCCGAACACCGCGCTGGGCCACAACTCGGTGGTGTTCATGATCGAGCAGCAGATTCGCTACGTCGGGCAGGCCATCGCCGCCGTCGACAAGGCGGGCGCGGCCGCGTTGGCGCCGACCCGGCGCGCGCAGGACGCGTTCAACGCCGAGTTGCAGCGGGATTTGTCCGGCACGGTGTTCAACACGGGCGGTTGCAAGAGCTGGTACCTCGACGAGCACGGCGTCAACCGGACGCTGTGGAGCGGCATGACATGGCAGTACTGGAAGGCGCTGCGCCGCCTCGATCCGTCGGAGTTCGAGTTCCTCGACCAGCGGGTTCTCGCGCGATCCTAG

Protein Sequence

MTAADQQPIRTRALVIGTGFSGLGMAIELQRRGVDFLILEKADEIGGTWRDNTYPGCACDIPSHMYSFSFEPKADWKHMWSFQPEIQDYLLGVTAKYGLRRHIHFNSHVDRAHWDDEELRWHVFTKTGQEYIAQFLVSGAGGLHIPQIPDIEGRESFAGAAFHSAQWDHSVDLRGKRVAVIGTGASAIQIVPEIVKDVAELHLYQRTPAWVMPRVNNAFPQWLRNVFSYVPGTRALLRAAIYWIHEGVGFAMTKEPRLLKIGEWMGRYNINRSIKDPELRRKLTPSYRAGCKRILNSDTYYRGIADPKTQVITEGIARMTPTGIVTNDGVEHPVDIVVYATGFHVTDSYTYVDIKGAGGEDLVDRWNREGIQAHRGVAVAGMPNLFFLLGPNTALGHNSVVFMIEQQIRYVGQAIAAVDKAGAAALAPTRRAQDAFNAELQRDLSGTVFNTGGCKSWYLDEHGVNRTLWSGMTWQYWKALRRLDPSEFEFLDQRVLARS_ 
Gene not present in the RLC0011 CRISPRi library.

Specific References

General References